Registration Dossier
Registration Dossier
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EC number: 212-073-8 | CAS number: 759-94-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This animal study is not performed according to GLP, but the test parameters are well documented and scientifically acceptable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Draize, J.H , Woodard, G., Calvery, H.O. (1944) J.Pharmacol. Expt. Ther. 82, 377-390
- Principles of method if other than guideline:
- Draize, J.H , Woodard, G., Calvery, H.O. (1944) J.Pharmacol. Expt. Ther. 82, 377-390
- GLP compliance:
- no
Test material
- Reference substance name:
- EPTC
- EC Number:
- 212-073-8
- EC Name:
- EPTC
- Cas Number:
- 759-94-4
- Molecular formula:
- C9H19NOS
- IUPAC Name:
- N,N-dipropyl(ethylsulfanyl)formamide
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New-Zealand albino
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Observation period (in vivo):
- 24 h, 48 h, 72 h
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: mean 24, 48 and 72 h
- Score:
- ca. 48.7
- Max. score:
- 70
- Reversibility:
- not specified
- Irritation parameter:
- cornea opacity score
- Remarks on result:
- other: Overall irritation score 70
- Remarks:
- Overall irritation score 70
- Irritation parameter:
- conjunctivae score
- Remarks on result:
- other: Overall irritation score 70
- Remarks:
- Overall irritation score 70
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information H 319 Szem irit cat 2 Criteria used for interpretation of results: EU
- Executive summary:
The EPTC substance is reported to be moderately irritative ( mérsékelten irritatív). H 319 Szemirritáció 2. kategória
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