Registration Dossier
Registration Dossier
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EC number: 212-073-8 | CAS number: 759-94-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This animal study is not performed according to GLP, but the test parameters are well documented and scientifically acceptable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Draize, J.H , Woodard, G., Calvery, H.O. (1944) J.Pharmacol. Expt. Ther. 82, 377-390
- Principles of method if other than guideline:
- Draize, J.H , Woodard, G., Calvery, H.O. (1944) J.Pharmacol. Expt. Ther. 82, 377-390
- GLP compliance:
- no
Test material
- Reference substance name:
- EPTC
- EC Number:
- 212-073-8
- EC Name:
- EPTC
- Cas Number:
- 759-94-4
- Molecular formula:
- C9H19NOS
- IUPAC Name:
- N,N-dipropyl(ethylsulfanyl)formamide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand albino
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Observation period:
- 24 h and 72 h
- Number of animals:
- 2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 h mean
- Score:
- ca. 4.75
- Max. score:
- 7
- Reversibility:
- no data
- Remarks on result:
- other: moderately irritating
- Irritation parameter:
- edema score
- Remarks on result:
- other: PDII=7
- Remarks:
- PDII=7
- Irritation parameter:
- erythema score
- Remarks on result:
- other: PDII=7
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information H315 Criteria used for interpretation of results: EU
- Conclusions:
- The EPTC substance is reported to be moderately irritative ( mérsékelten irritatív) according to Draize scoring system. H 315 bőrirritáció 2. kategória
- Executive summary:
The EPTC substance is reported to be moderately irritative ( mérsékelten irritatív). H 315 Bőrirritáció 2. kategória
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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