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EC number: 251-882-0 | CAS number: 34206-40-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin sensitisation: Key study: Based on the read-across approach from experimental data on analogue butan-2-one O,O',O''-(methylsilanetriyl)oxime (guinea-pig maximisation test, GLP study), the substance butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be skin sensitiser.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue butan-2-one O,O',O''-(methylsilylidyne)trioxime which shares the same functional group with butan-2-one O,O',O'',O'''-silanetetrayltetraoxime, also has comparable values for the relevant molecular properties for skin sensitisation.
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 50%
- No. with + reactions:
- 14
- Total no. in group:
- 14
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 50%. No with. + reactions: 14.0. Total no. in groups: 14.0.
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 28
- Group:
- test chemical
- Dose level:
- 50%
- No. with + reactions:
- 14
- Total no. in group:
- 15
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 28.0. Group: test group. Dose level: 50%. No with. + reactions: 14.0. Total no. in groups: 15.0.
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 50%
- No. with + reactions:
- 1
- Total no. in group:
- 3
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: 50%. No with. + reactions: 1.0. Total no. in groups: 3.0.
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 48
- No. with + reactions:
- 0
- Total no. in group:
- 3
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. Dose level: 48. No with. + reactions: 0.0. Total no. in groups: 3.0.
- Reading:
- 1st reading
- Group:
- positive control
- Remarks on result:
- other: No details given
- Interpretation of results:
- sensitising
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Based on the read-across approach from experimental results on analogue butan-2-one O,O',O''-(methylsilylidyne)trioxime, the read-across approach was applied and the substance butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be skin sensitiser.
- Executive summary:
A guinea-pig maximisation test was conducted according to OECD 406 and GLP on the analogue substance butan-2-one O,O',O''-(methylsilylidyne)trioxime. 15 female guinea pigs were exposed to induction doses of 5% (intradermal) and 25% (epicutaneous) and a challenge dose of 50% test item. Another 3 females were used as negative controls. The results on the analogue reported a response to challenge in 14 of 15 animals at 24 and 48 h. Responses in 1 of 3 and 0 of 3 were reported at 24 and 48 hours, respectively, in the small negative control group. Based on these results, the read-across approach was applied and the substance butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be skin sensitiser since a response of 30% or more in an adjuvant test indicates sensitisation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Skin sensitisation:
Key study: A guinea-pig maximisation test was conducted with GLP was performed on analogue substance butan-2-one O,O',O''-(methylsilylidyne)trioxime. The results reported a response to challenge (using 50% test substance) in 14 of 15 animals at 24 and 48 h. Responses in 1 of 3 and 0 of 3 were reported at 24 and 48 hours, respectively, in the small negative control group. A response of 30% or more in an adjuvant test indicates sensitisation. Based on this experimental data, a read-across approach was applied and the substance butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be skin sensitiser.
Justification for selection of skin sensitisation endpoint:
Only one study available.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available information, the test substance butan-2-one O,O',O'',O'''-silanetetrayltetraoxime is classified as Sensitiser Category 1B according to CLP Regulation (EC) No 1272/2008 (>30 responding at >1% intradermal induction dose).
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