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EC number: 231-829-8 | CAS number: 7758-01-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Apr 8-9, 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The present study was performed within the framework of toxicity studies of chemicals required by regulatory authorities in accordance with the presently valid OECD Guideline 431 and the Council Regulation (EC) No. 440/2008 and was performed in compliance with the Good Laboratory Practice (GLP) regulations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 431
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Potassium bromate
- EC Number:
- 231-829-8
- EC Name:
- Potassium bromate
- Cas Number:
- 7758-01-2
- Molecular formula:
- BrHO3.K
- IUPAC Name:
- potassium bromate
- Details on test material:
- Synonym: Potassium bromate
Constituent 1
Test system
- Type of coverage:
- other: in vitro human skin model
- Preparation of test site:
- other: in vitro human skin model
- Vehicle:
- water
- Amount / concentration applied:
- For the test item 20 mg, for positive and negative controls 40 µL were dosed per tissue
- Observation period:
- 3 min, 1 h
- Details on study design:
- Positive control: Potassium hydroxide
Negative control: Distilled water
Results and discussion
Any other information on results incl. tables
dose group | treatment interval | mean optical density | mean relative viability [%] |
neg. control | 3 min | 1.668 | 100.0 |
1 h | 2.045 | 100.0 | |
pos. control | 3 min | 0.310 | 18.60 |
1 h | 0.374 | 18.30 | |
Potassium bromate | 3 min | 1.925 | 115.41 |
1 h | 1.890 | 92.43 |
Treatment with the positive control induced a sufficient decrease in the relative absorbance as compared to the negative control for the treatment interval thus ensuring the validity of the test system.
After treatment with the negative control the absorbance values reached the required acceptability criterion of an OD >0.8 for the treatment interval thus showing the quality of the tissues.
The mean relative tissue viability after treatment with the test item was not significantly decreased after treatment. Therefore, the test item is not considered to possess a corrosive potential.
Applicant's summary and conclusion
- Interpretation of results:
- other: not corrosive
- Conclusions:
- Under the experimental conditions reported, potassium bromate is not corrosive to skin.
- Executive summary:
- Purpose
The purpose of this assay was to identify potential of potassium bromate for skin corrosion using an in vitro method as defined by the OECD Technical Guideline for Testing of Chemicals no 431.
Study Design
The test consisted of a topical exposure of the test item to a human reconstructed model followed by a cell viability test. Cell viability was measured by dehydrogenase conversion of MTT into a blue formazan salt, that was quantitatively measured after extraction from tissues. The percent reduction of cell viability in comparison to untreated negative controls was used to predict skin corrosion.
Triplicates of the human skin model RHE were treated either with the negative or the positive control for 3 minutes and 1 hour. 40 µL of the negative control (distilled water) or 40 µL of the positive control (potassium hydroxide, 8N) were applied to three tissues, respectively. For the test item, potassium bromate, three tissue per time point (3 minutes and 1 hour) was used. 20 mg of the test item were applied to each tissue, spread to match the tissue size.
Results
Treatment with the positive control induced a sufficient decrease in the relative absorbance as compared to the negative control for the treatment interval thus ensuring the validity of the test system.
After treatment with the negative control the absorbance values reached the required acceptability criterion of an optical density (OD) >0.8 for the treatment interval thus showing the quality of the tissues.
The mean relative tissue viability after treatment with the test item (potassium bromate) was not significantly decreased after treatment. Therefore, the test item is not considered to possess a corrosive potential.
Conclusion
Under the experimental conditions reported, potassium bromate is not corrosive to skin.
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