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Administrative data

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Description of key information

The serum half life of elimination of an orally administered dose is approximately 21 hours and the elimination half life for the liver is approximately 21 hours.

Key value for chemical safety assessment

Additional information

C4 Acrylate is absorbed when animals are dosed via gavage. Animals that received 30 mg/kg C4 acrylate had average total fluorine concentrations in serum of 6.0 ppm four hours post-dose, 12.1 ppm 28 hours post-dose, and 1.1 ppm 100 hours post dose. The apparent serum T1/2 of elimination of C4 acrylate was approximately 21 hours. The average liver total fluorine concentrations were 9.6, 12.7, and 2.6 ppm on day 0 (4 hours), day 1 (28 hours), and day 4 (100 hours) post dose, respectively. The estimated elimination rates were practically the same in the liver as they were in the serum.

 

Data is not available for dermal absorption but the half life of elimination would be expected to be similar to that seen in the gavage study. In the dermal toxicity study, effects similar to those seen in an acute oral study were seen so it is plausible that C4 acrylate may be absorbed through the skin. It is noted that the LD50 Dermal is greater than 2000 mg/kg.