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Diss Factsheets
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EC number: 200-143-0 | CAS number: 52-51-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication, meets generally accepted scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- The most frequent contact allergens of the years 2007 to 2009 - Current data of the Information Network of Departments of Dermatology
- Author:
- Geier J, Uter W, Krautheim A, Lessmann, H, Schnuch, A
- Year:
- 2 011
- Bibliographic source:
- Allergo-J 20: 93-101 [article in German]
Materials and methods
- Study type:
- case control study (retrospective)
- Endpoint addressed:
- skin sensitisation
- Principles of method if other than guideline:
- Epidemiological surveilance of contact sensitization with presentation of the most frequent contact allergens.
Analysis of data of the Information Network of Departments of Dermatology (IVDK) of the years 2007 to 2009.
Test material
- Reference substance name:
- Bronopol
- EC Number:
- 200-143-0
- EC Name:
- Bronopol
- Cas Number:
- 52-51-7
- Molecular formula:
- C3H6BrNO4
- IUPAC Name:
- 2-bromo-2-nitropropane-1,3-diol
Constituent 1
Method
- Type of population:
- other: patients
- Ethical approval:
- not specified
- Details on study design:
- patch testing
- Statistical methods:
- Statistical analysis of data of the Information Network of Departments of Dermatology (IVDK) of the years 2007 to 2009. Patch test reactions assessed on day 3 (or day 4) were evaluated.
For the evaluation of test results, a statistical analysis was performed according to the guidelines for the descriptive presentation and statistaical of contact allergy data by means of the software package SAS 9.1 (SAS Institute, Cary NC, U.S.A.).
Results and discussion
- Results:
- Bronopol - Relative response rate in % (95% coincidence interval)
Women (n = 21.250): 1.3 (1.2 - 1.5),
Men (n = 12841): 1.6 (1.4 - 1.9)
During the study period, 34,091 patients havc been patch tested in the departments of dermatology forming the IVDK. Compared to the years before, reactions tonickel sulphate, cobalt chloride and potassium dichromate were significantly less frequent in 2009 than before. The preservative methyldibromo glutaronitrile(MDBGN) elicited signitlcantly less positive reactions already from 2008 on. The proportion of positive reactions to the fragrance hydroxyisohexyl 3-cydohexene carboxaldehyde (HICC, LYRAL) was considerably, albeit not significantly, lower in 2009, when compared to 2007and 2008. Sensitization frequency to bufexamac has been at a constant level for years.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.