Korábbi/eredmények

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

1 996 eredményből 801 - 1 000 megmutatása.

Name	EC Number	CAS Number	Hazard endpoint for which vertebrate testing was proposed	Date of publication to call for available information	Deadline for submitting information
2-phosphonobutane-1,2,4-tricarboxylic acid	253-733-5	37971-36-1	Long-term toxicity to fish\|\|Note: testing proposed with Tetrasodium hydrogen 2-phosphonatobutane-1,2,4-tricarbolxyate, (EC No. 266-442-3) Reproductive toxicity (pre-natal developmental toxicity)\|\|Note: testing proposed with Tetrasodium hydrogen 2-phosphonatobutane-1,2,4-tricarbolxyate, (EC No. 266-442-3)	26/10/2022 26/10/2022	12/12/2022 12/12/2022	Details
2-Oxepanone, polymer with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol	500-099-5	37625-56-2	Reproductive toxicity (pre-natal developmental toxicity)	15/07/2011	29/08/2011	Details
2,4-Pentanedione, peroxide	253-384-9	37187-22-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	30/11/2015 30/11/2015	14/01/2016 14/01/2016	Details
Octa-1,7-diene	223-054-9	3710-30-3	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/02/2014 18/02/2014	04/04/2014 04/04/2014	Details
(E)-1,1,1,2,3,4,5,5,5-Nonafluoro-4-(trifluoromethyl)pent-2-ene	807-113-1	3709-71-5	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation	19/10/2020 19/10/2020	03/12/2020 03/12/2020	Details
2-Oxepanone, polymer with 1,6-hexanediol	609-271-5	36609-29-7	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with 2-Oxepanone, polymer with 1,4-butanediol Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with 2-Oxepanone, polymer with 1,4-butanediol	16/10/2014 16/10/2014	01/12/2014 01/12/2014	Details
2,2-dimethylpropan-1-ol, tribromo derivative	253-057-0	36483-57-5	Reproductive toxicity (pre-natal developmental toxicity)	17/04/2015	04/06/2015	Details
Diundecyl phthalate	222-884-9	3648-20-2	Reproductive toxicity (pre-natal developmental toxicity)	25/11/2021	10/01/2022	Details
Dioctyltin dilaurate	222-883-3	3648-18-8	Reproductive toxicity (pre-natal developmental toxicity)	23/03/2020	07/05/2020	Details
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with maleic anhydride and methacrylic acid	500-090-6	36425-16-8	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with a structurally related substance (small vinyl ester) Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with a structurally related substance (small vinyl ester)	31/05/2016 31/05/2016	15/07/2016 15/07/2016	Details
4,4`-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with methacrylic acid	500-089-0	36425-15-7	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	01/07/2011 01/07/2011 01/07/2011	15/08/2011 15/08/2011 15/08/2011	Details
N-butylbenzenesulphonamide	222-823-6	3622-84-2	Reproductive toxicity (pre-natal developmental toxicity)	14/02/2011	31/03/2011	Details
N-butylbenzenesulphonamide	222-823-6	3622-84-2	Reproductive toxicity (pre-natal developmental toxicity)	29/02/2016	14/04/2016	Details
N-butyl-2,2,6,6-tetramethylpiperidin-4-amine	252-899-6	36177-92-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): ora	07/10/2016 07/10/2016	21/11/2016 21/11/2016	Details
Phosphonium, tetrakis(hydroxymethyl)-, chloride (1:1), reaction products with 1-tetradecanamine and urea	436-230-7	359406-89-6	Sub-chronic toxicity (90-day): oral	06/03/2012	20/04/2012	Details
N,N''-propane-1,3-diylbis[N'-octadecylurea	252-667-4	35674-65-8	Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity)	29/03/2016	13/05/2016	Details
Triethoxy(2,4,4-trimethylpentyl)silane	252-558-1	35435-21-3	Long-term toxicity to fish \|\| Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates. Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with triethoxyoctylsilane (CAS 2943-75-1)	28/02/2018 28/02/2018	16/04/2018 16/04/2018	Details
Triethoxy(2,4,4-trimethylpentyl)silane	252-558-1	35435-21-3	Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	29/04/2011 29/04/2011	14/06/2011 14/06/2011	Details
Trinonyl benzene-1,2,4-tricarboxylate	252-552-9	35415-27-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	11/11/2016 11/11/2016	03/01/2017 03/01/2017	Details
Propanamide, 2-hydroxy-N,N-dimethyl-	609-066-0	35123-06-9	Reproductive toxicity (extended one-generation reproductive toxicity study)	18/03/2021	03/05/2021	Details
Propanamide, 2-hydroxy-N,N-dimethyl-	609-066-0	35123-06-9	Reproductive toxicity (extended one-generation reproductive toxicity study)	21/10/2021	07/12/2021	Details
Sodium 2-[(2-aminoethyl)amino]ethanesulphonate	252-173-9	34730-59-1	Reproductive toxicity (pre-natal developmental toxicity)	29/04/2014	13/06/2014	Details
triethoxy(3-thiocyanatopropyl)silane	252-161-3	34708-08-2	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/10/2014 16/10/2014 16/10/2014	01/12/2014 01/12/2014 01/12/2014	Details
1-butylpyrrolidin-2-one	222-437-8	3470-98-2	Reproductive toxicity (extended one-generation reproductive toxicity study)	25/01/2022	11/03/2022	Details
[[(phosphonomethyl)imino]bis[hexamethylenenitrilobis(methylene)]]tetrakisphosphonic acid	252-156-6	34690-00-1	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: Testing proposal is based on concern identified by the registrant. Sub-chronic toxicity (90-day): oral \|\| Note: Testing proposal is based on concern identified by the registrant.	20/05/2015 20/05/2015	06/07/2015 06/07/2015	Details
[[(phosphonomethyl)imino]bis[hexamethylenenitrilobis(methylene)]]tetrakisphosphonic acid	252-156-6	34690-00-1	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with either the registered substance or a read-across substance, which would be a salt of the same phosphonic acid; or salt of a structurally analogous phosphonic acid, HMDTMP Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with either the registered substance or a read-across substance, which would be a salt of the same phosphonic acid; or salt of a structurally analogous phosphonic acid, HMDTMP	31/01/2018 31/01/2018	19/03/2018 19/03/2018	Details
1-imino-1H-isoindol-3-amine	222-426-8	3468-11-9	Genetic toxicity in vivo	18/03/2021	03/05/2021	Details
1-imino-1H-isoindol-3-amine	222-426-8	3468-11-9	Genetic toxicity in vivo	27/01/2020	12/03/2020	Details
tert-butyl α,α-dimethylbenzyl peroxide	222-389-8	3457-61-2	Long-term toxicity to fish \|\| Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates	16/03/2015	30/04/2015	Details
tert-butyl α,α-dimethylbenzyl peroxide	222-389-8	3457-61-2	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/07/2014 15/07/2014	29/08/2014 29/08/2014	Details
Tris(nitrato-O)nitrosylruthenium	252-068-8	34513-98-9	Genetic toxicity in vivo	01/07/2021	16/08/2021	Details
Carboxymethyldimethyl-3-[[(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)sulphonyl]amino]propylammonium hydroxide	252-046-8	34455-29-3	Long-term toxicity to fish	03/10/2023	17/11/2023	Details
Carboxymethyldimethyl-3-[[(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)sulphonyl]amino]propylammonium hydroxide	252-046-8	34455-29-3	Reproductive toxicity (extended one-generation reproductive toxicity study) Sub-chronic toxicity (90-day): oral	16/12/2020 16/12/2020	01/02/2021 01/02/2021	Details
1-(2-hydroxyethyl)pyrrolidin-2-one	222-359-4	3445-11-2	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/12/2020 16/12/2020 16/12/2020	01/02/2021 01/02/2021 01/02/2021	Details
1-(2-hydroxyethyl)pyrrolidin-2-one	222-359-4	3445-11-2	Reproductive toxicity (pre-natal developmental toxicity)	14/08/2014	28/09/2014	Details
OO-tert-butyl O-(2-ethylhexyl) peroxycarbonate	252-029-5	34443-12-4	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	21/03/2014 21/03/2014 21/03/2014	05/05/2014 05/05/2014 05/05/2014	Details
OO-tert-butyl O-(2-ethylhexyl) peroxycarbonate	252-029-5	34443-12-4	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	21/01/2021 21/01/2021	08/03/2021 08/03/2021	Details
trimethoxy(2,4,4-trimethylpentyl)silane	251-995-5	34396-03-7	Long-term toxicity to fish	26/10/2022	12/12/2022	Details
trimethoxy(2,4,4-trimethylpentyl)silane	251-995-5	34396-03-7	Sub-chronic toxicity (90-day): oral Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (EC 252-558-1, CAS 35435-21-3) "	25/06/2015	10/08/2015	Details
Bisisobutyryl peroxide	222-340-0	3437-84-1	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	04/04/2014 04/04/2014 04/04/2014	19/05/2014 19/05/2014 19/05/2014	Details
tert-pentyl hydroperoxide	222-321-7	3425-61-4	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	07/10/2016 07/10/2016	21/11/2016 21/11/2016	Details
tert-pentyl hydroperoxide	222-321-7	3425-61-4	Genetic toxicity in vivo	21/03/2014	05/05/2014	Details
Oleic acid, compound with (Z)-N-octadec-9-enylpropane-1,3-diamine (2:1)	251-846-4	34140-91-5	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity)	10/05/2022 10/05/2022	27/06/2022 27/06/2022	Details
3-Ethenyl-5-methyl-2-oxazolidinone	809-852-5	3395-98-0	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	27/09/2017 27/09/2017	13/11/2017 13/11/2017	Details
Sodium hexahydroxoantimonate	251-735-0	33908-66-6	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/07/2011 15/07/2011	29/08/2011 29/08/2011	Details
Perfluamine	206-420-2	338-83-0	Genetic toxicity in vivo (In vivo Mammalian Alkaline Comet Assay) Genetic toxicity in vivo (Mammalian Erythrocyte Micronucleus Test) Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	29/03/2019 29/03/2019 29/03/2019 29/03/2019	13/05/2019 13/05/2019 13/05/2019 13/05/2019	Details
Perfluamine	206-420-2	338-83-0	Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	21/12/2021 21/12/2021 21/12/2021	04/02/2022 04/02/2022 04/02/2022	Details
1,2,3,5,6,7-hexahydro-1,1,2,3,3-pentamethyl-4H-inden-4-one	251-649-3	33704-61-9	Reproductive toxicity (pre-natal developmental toxicity)	30/06/2023	14/08/2023	Details
Diisononyl adipate	251-646-7	33703-08-1	Long-term toxicity to fish\|\|Note: Read across testing proposed with Bis(2-ethylhexyl) adipate (EC no. 203-090-1) Reproductive toxicity (extended one-generation reproductive toxicity study)\|\|Note: Read across testing proposed with Bis(2-ethylhexyl) adipate (EC no. 203-090-1)	03/05/2023 03/05/2023	19/06/2023 19/06/2023	Details
sodium O,O-diethyl dithiophosphate \|\| Note: testing proposed with sodium O,O-diisobutyl dithiophosphate (EC 258-508-5)	222-079-2	3338-24-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/09/2014 18/09/2014	03/11/2014 03/11/2014	Details
N,N-bis[3-(dimethylamino)propyl]-N',N'-dimethylpropane-1,3-diamine	251-459-0	33329-35-0	Reproductive toxicity (two-generation reproductive toxicity) Note: testing proposed with structurally-related compound	29/04/2014	13/06/2014	Details
Propylidynetrimethyl trimethacrylate	221-950-4	3290-92-4	Reproductive toxicity (extended one-generation reproductive toxicity study)	26/04/2019	10/06/2019	Details
Propylidynetrimethyl trimethacrylate	221-950-4	3290-92-4	Reproductive toxicity (pre-natal developmental toxicity)	31/05/2016	15/07/2016	Details
1,1,3,3-tetramethyldisiloxane	221-906-4	3277-26-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation	29/04/2016 29/04/2016	13/06/2016 13/06/2016	Details
3,4,5,6,7,8,9,10,11,12,13,14-dodecahydro-2H-cyclododeca[b]pyran	251-090-5	32539-83-6	Genetic toxicity in vivo	14/02/2011	31/03/2011	Details
Ethylene bis[3,3-bis(3-tert-butyl-4-hydroxyphenyl)butyrate]	251-073-2	32509-66-3	Reproductive toxicity (pre-natal developmental toxicity)	31/01/2014	17/03/2014	Details
4,4'-Isopropylidenediphenol, ethoxylated	500-082-2	32492-61-8	Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	16/06/2022 16/06/2022 16/06/2022	01/08/2022 01/08/2022 01/08/2022	Details
2-benzofuran-1,3-dione; 2-(2-hydroxyethoxy)ethanol	608-744-3	32472-85-8	Reproductive toxicity (pre-natal developmental toxicity)	16/03/2015	30/04/2015	Details
Furan-2,5-dicarboxylic acid	221-800-8	3238-40-2	Reproductive toxicity (pre-natal developmental toxicity)	27/05/2019	11/07/2019	Details
4-tert-butylcyclohexyl acetate	250-954-9	32210-23-4	Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with cis-4-tert-butylcyclohexyl acetate	24/02/2020	09/04/2020	Details
Hydroxyethylated 2-butyne-1,4-diol	608-711-3	32167-31-0	Sub-chronic toxicity (90-day): oral	17/06/2014	01/08/2014	Details
Formaldehyde, oligomeric reaction products with aniline and phosgene	500-079-6	32055-14-4	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC 202-966-0)	01/04/2022	16/05/2022	Details
2,2,4(or 2,4,4)-Trimethylhexane-1,6-diisocyanate	915-277-1	32052-51-0	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): inhalation	02/06/2014 02/06/2014	17/07/2014 17/07/2014	Details
Ethane- 1,2-diol, propoxylated	500-078-0	31923-84-9	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	05/07/2018 05/07/2018 05/07/2018	20/08/2018 20/08/2018 20/08/2018	Details
2-Oxepanone, polymer with 1,4-butanediol	608-670-1	31831-53-5	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/05/2014 16/05/2014	30/06/2014 30/06/2014	Details
Tris(2,4-ditert-butylphenyl) phosphite	250-709-6	31570-04-4	Reproductive toxicity (pre-natal developmental toxicity)	28/11/2022	12/01/2023	Details
3-(dimethylamino)propylurea	401-950-2	31506-43-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	06/06/2023 06/06/2023	21/07/2023 21/07/2023	Details
2-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol	221-573-5	3147-75-9	Bioaccumulation aquatic / sediment	15/07/2014	29/08/2014	Details
2-methoxyethyl acrylate	221-499-3	3121-61-7	Genetic toxicity in vivo	21/03/2014	05/05/2014	Details
Potassium 3-sulphonatopropyl acrylate	250-465-0	31098-20-1	Genetic toxicity in vivo	17/06/2020	03/08/2020	Details
N-[3-(trimethoxysilyl)propyl]butylamine // Note: testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC No. 217-164-6)	250-437-8	31024-56-3	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/09/2014 18/09/2014	03/11/2014 03/11/2014	Details
p-tert-butylphenyl 1-(2,3-epoxy)propyl ether	221-453-2	3101-60-8	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	17/06/2014 17/06/2014 17/06/2014 17/06/2014	01/08/2014 01/08/2014 01/08/2014 01/08/2014	Details
A mixture of cis- and trans-cyclohexadec-8-en-1-one	401-700-2	3100-36-5	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	28/11/2022 28/11/2022 28/11/2022	12/01/2023 12/01/2023 12/01/2023	Details
tris[2-[2-(2-methoxyethoxy)ethoxy]ethyl] orthoborate	250-418-4	30989-05-0	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	28/02/2011 28/02/2011 28/02/2011	14/04/2011 14/04/2011 14/04/2011	Details
tris[2-[2-(2-methoxyethoxy)ethoxy]ethyl] orthoborate	250-418-4	30989-05-0	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	29/04/2016 29/04/2016	13/06/2016 13/06/2016	Details
Fatty acids, C12-14 (even numbered), methyl ester	629-776-4	308065-15-8	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	30/09/2021 30/09/2021 30/09/2021	15/11/2021 15/11/2021 15/11/2021	Details
trimethoxyoctylsilane	221-338-7	3069-40-7	Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (CAS 35435-21-3)	07/08/2015	22/09/2015	Details
Trimethoxyoctylsilane	221-338-7	3069-40-7	Reproductive toxicity (extended one-generation reproductive toxicity study \|\| Note: testing proposed with triethoxyoctylsilane (CAS 2943-75-1) Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with triethoxyoctylsilane (CAS 2943-75-1)	27/09/2017 27/09/2017	13/11/2017 13/11/2017	Details
N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine	221-336-6	3069-29-2	Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with N-(3-trimethoxysilyl)propyl)ethylenediamine CAS 1760-24-3. Sub-chronic toxicity (90-day): oral Note: testing proposed with N-(3-trimethoxysilyl)propyl)ethylenediamine CAS 1760-24-3.	25/06/2015 25/06/2015	10/08/2015 10/08/2015	Details
2-isocyanatoethyl methacrylate	250-284-7	30674-80-7	Reproductive toxicity (pre-natal developmental toxicity)	23/03/2020	07/05/2020	Details
Tetra(isobutyl)thioperoxydicarbamic acid	221-312-5	3064-73-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/06/2018 18/06/2018	02/08/2018 02/08/2018	Details
4,4'-Isopropylidenedicyclohexanol, oligomeric reaction products with 1-chloro-2,3-epoxypropane	500-070-7	30583-72-3	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	02/06/2014 02/06/2014 02/06/2014 02/06/2014	17/07/2014 17/07/2014 17/07/2014 17/07/2014	Details
Reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane	608-489-8	30499-70-8	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	25/06/2015 25/06/2015 25/06/2015	10/08/2015 10/08/2015 10/08/2015	Details
3-ethyloxetane-3-methanol	221-254-0	3047-32-3	Long-term toxicity to fish	03/10/2023	17/11/2023	Details
3-ethyloxetane-3-methanol	221-254-0	3047-32-3	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	31/01/2014 31/01/2014	17/03/2014 17/03/2014	Details
hex-3-yne-2,5-diol	221-209-5	3031-66-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/09/2014 18/09/2014	03/11/2014 03/11/2014	Details
bis(2-dimethylaminoethyl)(methyl)amine	221-201-1	3030-47-5	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	03/03/2014 03/03/2014	17/04/2014 17/04/2014	Details
Hexyl 2-(1-(diethylaminohydroxyphenyl)methanoyl)benzoate	443-860-6	302776-68-7	Long-term toxicity to fish	16/08/2011	30/09/2011	Details
Hydrazine	206-114-9	302-01-2	Sub-chronic toxicity (28 day): inhalation	15/07/2011	29/08/2011	Details
Cyclohexylidenebis[tert-butyl] peroxide	221-111-2	3006-86-8	Sub-chronic toxicity (90-day): oral	21/03/2014	05/05/2014	Details
tert-butyl 2-ethylperoxyhexanoate	221-110-7	3006-82-4	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/04/2011 15/04/2011 15/04/2011	30/05/2011 30/05/2011 30/05/2011	Details
3,9-dimethyl-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane 3,9-dioxide	221-088-9	3001-98-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/12/2020 16/12/2020	01/02/2021 01/02/2021	Details
5-bromo-5-nitro-1,3-dioxane	250-001-7	30007-47-7	Genetic toxicity in vivo	19/10/2020	03/12/2020	Details
2,2'-azobis[2-methylpropionamidine] dihydrochloride	221-070-0	2997-92-4	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	05/07/2018 05/07/2018	20/08/2018 20/08/2018	Details
Isodecyl methacrylate	249-978-2	29964-84-9	Long-term toxicity to fish Sub-chronic toxicity (90-day): oral	03/10/2023 03/10/2023	17/11/2023 17/11/2023	Details
Trimethoxyphenylsilane	221-066-9	2996-92-1	Reproductive toxicity (pre-natal developmental toxicity)	03/03/2014	17/04/2014	Details
Sodium hydrogen N-(1-oxododecyl)-L-glutamate	249-958-3	29923-31-7	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with CAS 68187-30-4	16/05/2014	30/06/2014	Details
Dichloromethylbenzene	249-854-8	29797-40-8	Reproductive toxicity (extended one-generation reproductive toxicity study)	22/06/2017	07/08/2017	Details
Dichloromethylbenzene	249-854-8	29797-40-8	Reproductive toxicity (pre-natal developmental toxicity)	31/01/2014	17/03/2014	Details
Dichloromethylbenzene	249-854-8	29797-40-8	Reproductive toxicity (pre-natal developmental toxicity)	15/09/2011	31/10/2011	Details
Isodecyl diphenyl phosphate	249-828-6	29761-21-5	Bioaccumulation aquatic / sediment	15/07/2011	29/08/2011	Details
Isooctyl acrylate	249-707-8	29590-42-9	Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	15/03/2011 15/03/2011	29/04/2011 29/04/2011	Details
Triethoxyoctylsilane	220-941-2	2943-75-1	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	27/09/2017 27/09/2017 27/09/2017	13/11/2017 13/11/2017 13/11/2017	Details
Triethoxyoctylsilane	220-941-2	2943-75-1	Long-term toxicity to fish \|\| Note: testing proposed with Triethoxy(2,4,4-trimethylpentyl)silane (EC 252-558-1)	17/04/2015	04/06/2015	Details
methyl-1h-benzotriazole	249-596-6	29385-43-1	Sub-chronic toxicity (90-day): oral	16/12/2020	01/02/2021	Details
methyl-1h-benzotriazole	249-596-6	29385-43-1	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with either Benzotriazole, Tolyltriazole, Sodium Benzotriazolate, or Sodium Tolyltriazolate	16/12/2016	30/01/2017	Details
[3-(2,3-epoxypropoxy)propyl]diethoxymethylsilane	220-780-8	2897-60-1	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant.	16/12/2016	30/01/2017	Details
2,2,6,6-tetramethyl-4-oxopiperidinooxy	220-778-7	2896-70-0	Sub-chronic toxicity (90-day): oral	03/04/2023	22/05/2023	Details
2,2,6,6-tetramethyl-4-oxopiperidinooxy	220-778-7	2896-70-0	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with 4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl (CAS No 2226-96-2) Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with 4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl (CAS No 2226-96-2)	14/08/2014 14/08/2014	28/09/2014 28/09/2014	Details
4,4'-methylenebis[N,N-bis(2,3-epoxypropyl)aniline]	249-204-3	28768-32-3	Reproduction toxicity (two generation reproductive toxicity) Reproductive toxicity (developmental toxicity) Sub-chronic toxicity (90-day): dermal	26/01/2011 26/01/2011 26/01/2011	14/03/2011 14/03/2011 14/03/2011	Details
N-(1,1-dimethyl-3-oxobutyl)acrylamide	220-713-2	2873-97-4	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	03/03/2014 03/03/2014	17/04/2014 17/04/2014	Details
Tetrasodium 7,7'-(carbonyldiimino)bis[4-hydroxy-3-[(6-sulphonato-2-naphthyl)azo]naphthalene-2-sulphonate]	249-171-5	28706-25-4	Reproductive toxicity (pre-natal developmental toxicity)	10/05/2022	27/06/2022	Details
3-(isodecyloxy)propylammonium acetate	249-166-8	28701-67-9	Reproductive toxicity (pre-natal developmental toxicity)	26/08/2021	11/10/2021	Details
Zinc bis(O,O-diisooctyl) bis(dithiophosphate)	249-109-7	28629-66-5	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“	04/10/2018 04/10/2018 04/10/2018	19/11/2018 19/11/2018 19/11/2018	Details
Zinc bis(O,O-diisooctyl) bis(dithiophosphate)	249-109-7	28629-66-5	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6) Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), and Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5)	21/12/2021 21/12/2021 21/12/2021	04/02/2022 04/02/2022 04/02/2022	Details
Di-''isononyl'' phthalate	249-079-5	28553-12-0	Reproductive toxicity (pre-natal developmental toxicity)	22/09/2022	07/11/2022	Details
Diisodecyl sebacate	249-047-0	28473-19-0	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	02/06/2014 02/06/2014	17/07/2014 17/07/2014	Details
Ditolyl ether	248-948-6	28299-41-4	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	21/10/2021 21/10/2021	07/12/2021 07/12/2021	Details
2-[(1-amino-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthryl)oxy]ethyl phenyl carbonate	248-882-8	28173-59-3	Genetic toxicity in vivo	23/11/2020	07/01/2021	Details
1,4-diazabicyclooctane	205-999-9	280-57-9	Reproductive toxicity (pre-natal developmental toxicity)	14/08/2014	28/09/2014	Details
1,4-diazabicyclooctane	205-999-9	280-57-9	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	26/10/2022 26/10/2022 26/10/2022	12/12/2022 12/12/2022 12/12/2022	Details
4-[[4-(aminocarbonyl)phenyl]azo]-N-(2-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide – nano form	220-509-3	2786-76-7	Reproductive toxicity (extended one-generation reproductive toxicity study)\|\|Note: testing proposed with [3-hydroxy-N-(o-tolyl)-4-[(2,4,5-trichlorophenyl)azo]naphthalene-2-carboxamide] (EC no. 229-440-3)	03/10/2023	17/11/2023	Details
Diethyl bis(2-hydroxyethyl)aminomethylphosphonate	220-482-8	2781-11-5	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant.	27/01/2020	12/03/2020	Details
Benzyltoluene	248-654-8	27776-01-8	Reproductive toxicity (pre-natal developmental toxicity)	18/02/2014	04/04/2014	Details
Benzyltoluene	248-654-8	27776-01-8	Long-term toxicity to fish (OECD 210)	25/06/2019	09/08/2019	Details
Vanadium oxide sulphate	248-652-7	27774-13-6	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with sodium metavanadate (EC 237-272-7) Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with sodium metavanadate (EC 237-272-7)	01/04/2022 01/04/2022	16/05/2022 16/05/2022	Details
Isotridecan-1-ol	248-469-2	27458-92-0	Reproductive toxicity (pre-natal developmental toxicity)	20/12/2017	05/02/2018	Details
Isotridecan-1-ol	248-469-2	27458-92-0	Reproductive toxicity (extended one-generation reproductive toxicity study)	16/12/2020	01/02/2021	Details
Neodecanoic acid, cobalt salt	248-373-0	27253-31-2	Reproductive toxicity (pre-natal developmental toxicity)\|\|Note: testing proposed with Neodecanoic acid, cobalt salt (EC no. 248-373-0)	28/11/2022	12/01/2023	Details
Neodecanoic acid, cobalt salt	248-373-0	27253-31-2	Genetic toxicity in vivo \|\| Note: testing proposed with Cobalt sulphate (EC 233-334-2) \|\| Note: Testing proposal is based on concern identified by the registrant	21/01/2021	08/03/2021	Details
2-ethylhexyl nitrate	248-363-6	27247-96-7	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90 day): inhalation	29/04/2011 29/04/2011 29/04/2011	14/06/2011 14/06/2011 14/06/2011	Details
Nonene	248-339-5	27215-95-8	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	31/05/2011 31/05/2011 25/06/2012	15/07/2011 15/07/2011 09/08/2012	Details
Oxydipropyl dibenzoate	248-258-5	27138-31-4	Long-term toxicity to fish	10/08/2018	24/09/2018	Details
α,α,α',α'-tetramethylxylene-α,α-diol	248-256-4	27138-01-8	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	14/08/2014 14/08/2014	28/09/2014 28/09/2014	Details
2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-octyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate	248-227-6	27107-89-7	Genetic toxicity in vivo	30/11/2015	14/01/2016	Details
2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-octyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate	248-227-6	27107-89-7	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/05/2011 16/05/2011 16/05/2011	30/06/2011 30/06/2011 30/06/2011	Details
Tetrakis(hydroxymethyl)phosphonium chloride, oligomeric reaction products with urea	500-057-6	27104-30-9	Sub-chronic toxicity (90-day): oral	02/09/2011	17/10/2011	Details
Octadecene	248-205-6	27070-58-2	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	31/05/2011 31/05/2011	15/07/2011 15/07/2011	Details
di-p-tolyl(2,4,6-trimethylbenzoyl)phosphine oxide	884-585-5	270586-78-2	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	30/06/2023 30/06/2023 30/06/2023	14/08/2023 14/08/2023 14/08/2023	Details
Allyl 3-cyclohexylpropionate	220-292-5	2705-87-5	Reproductive toxicity (pre-natal developmental toxicity)	26/10/2022	12/12/2022	Details
Hexadecene	248-131-4	26952-14-7	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	31/05/2011 31/05/2011 25/06/2012	15/07/2011 15/07/2011 09/08/2012	Details
Tetradecene	248-130-9	26952-13-6	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	31/05/2011 31/05/2011	15/07/2011 15/07/2011	Details
Tricyclodecanedimethanol	248-096-5	26896-48-0	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/08/2011 16/08/2011	30/09/2011 30/09/2011	Details
N-ethyl-2-pyrrolidone (NEP)	220-250-6	2687-91-4	Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day) via the inhalatory route	26/01/2011 26/01/2011	14/03/2011 14/03/2011	Details
Diisopropylbenzene hydroperoxide	247-988-1	26762-93-6	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/07/2014 15/07/2014	29/08/2014 29/08/2014	Details
2,3-epoxypropyl neodecanoate	247-979-2	26761-45-5	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	25/05/2020 25/05/2020	09/07/2020 09/07/2020	Details
2,3-epoxypropyl neodecanoate	247-979-2	26761-45-5	Reproductive toxicity (extended one-generation reproductive toxicity study)	23/04/2018	07/06/2018	Details
2,3-epoxypropyl neodecanoate	247-979-2	26761-45-5	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90 day): dermal	15/07/2014 15/07/2014 15/07/2014	29/08/2014 29/08/2014 29/08/2014	Details
2,3-epoxypropyl neodecanoate	247-979-2	26761-45-5	Reproductive toxicity (developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day)	26/05/2010 26/05/2010 26/05/2010	12/07/2010 12/07/2010 12/07/2010	Details
tert-butyl peroxyneodecanoate	247-955-1	26748-41-4	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	17/06/2014 17/06/2014	01/08/2014 01/08/2014	Details
Zinc bis[O-(2-ethylhexyl)] bis[O-(isobutyl)] bis(dithiophosphate)	247-810-2	26566-95-0	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with another ZDDP category member to be determined based on outcome of other testing proposals Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6) Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), and Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6)	21/12/2021 21/12/2021 21/12/2021	04/02/2022 04/02/2022 04/02/2022	Details
Zinc bis[O-(2-ethylhexyl)] bis[O-(isobutyl)] bis(dithiophosphate)	247-810-2	26566-95-0	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"	04/10/2018 04/10/2018	19/11/2018 19/11/2018	Details
Octanoic acid, monoester with glycerol	247-668-1	26402-26-6	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	03/10/2023 03/10/2023	17/11/2023 17/11/2023	Details
Dihexadecyl peroxodicarbonate	247-611-0	26322-14-5	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: Name of the substance on which testing is proposed to be carried out: ditetradecyl peroxydicarbonate (EC: 258-436-4) Sub-chronic toxicity (90-day): oral	23/04/2018 23/04/2018	07/06/2018 07/06/2018	Details
1,1,3,3-tetramethyl-1,3-divinyldisiloxane	220-099-6	2627-95-4	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	25/06/2015 25/06/2015	10/08/2015 10/08/2015	Details
1,3,5-tris[3-(trimethoxysilyl)propyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione	247-465-8	26115-70-8	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	03/10/2023 03/10/2023	17/11/2023 17/11/2023	Details
Bis(2-ethylhexyl) tetrabromophthalate	247-426-5	26040-51-7	Reproductive toxicity (pre-natal developmental toxicity)	16/05/2014	30/06/2014	Details
Orthoboric acid, compound with 2-aminoethanol	247-421-8	26038-87-9	Long-term or reproductive toxicity to birds Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	15/09/2011 15/09/2011 15/09/2011	31/10/2011 31/10/2011 31/10/2011	Details
Orthoboric acid, compound with 2-aminoethanol	247-421-8	26038-87-9	Repeated dose toxicity (90-day): oral	17/11/2011	02/01/2012	Details
[3-(2,3-epoxypropoxy)propyl]triethoxysilane	220-011-6	2602-34-8	Genetic toxicity in vivo	18/03/2021	03/05/2021	Details
Dimethyl 2,2'-azobis(2-methylpropionate)	219-976-6	2589-57-3	Genetic toxicity in vivo	17/06/2020	03/08/2020	Details
2,4,6-tris(2,4,6-tribromophenoxy)-1,3,5-triazine	426-040-2	25713-60-4	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	16/06/2011 16/06/2011 16/06/2011 16/06/2011	01/08/2011 01/08/2011 01/08/2011 01/08/2011	Details
4,4'-Methylenediphenyl diisocyanate, oligomers	500-040-3	25686-28-6	Reproductive toxicity (extended one-generation reproductive toxicity study)\|\| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no. 202-966-0)	16/06/2022	01/08/2022	Details
N-(2-(4-amino-N-ethyl-m-toluidino)ethyl)methanesulphonamide sesquisulphate	247-161-5	25646-71-3	Genetic toxicity in vivo	17/06/2020	03/08/2020	Details
2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane	219-863-1	2554-06-5	Genetic toxicity in vivo Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): inhalation	03/03/2014 03/03/2014 03/03/2014 03/03/2014	17/04/2014 17/04/2014 17/04/2014 17/04/2014	Details
4-phenylbutan-2-one	219-847-4	2550-26-7	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with a read-across substance having similar formula structure and its carbon chain consists of even number of carbons	22/11/2017	08/01/2018	Details
Triethoxypropylsilane	219-842-7	2550-02-9	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): inhalation	03/03/2014 03/03/2014	17/04/2014 17/04/2014	Details
Dodecene	246-922-9	25378-22-7	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	31/05/2011 31/05/2011	15/07/2011 15/07/2011	Details
Octene	246-920-8	25377-83-7	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with hex-1-ene Sub-chronic toxicity (90-day): oral	02/06/2014 02/06/2014	17/07/2014 17/07/2014	Details
Tridecene	246-919-2	25377-82-6	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	31/05/2011 31/05/2011	15/07/2011 15/07/2011	Details
2,2'-methylenediphenyl diisocyanate	219-799-4	2536-05-2	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no. 202-966-0)	01/04/2022	16/05/2022	Details
Decene	246-870-7	25339-53-1	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	31/05/2011 31/05/2011 25/06/2012	15/07/2011 15/07/2011 09/08/2012	Details
2,2'-(octadec-9-enylimino)bisethanol	246-807-3	25307-17-9	Reproductive toxicity (extended one-generation reproductive toxicity study)	01/09/2017	16/10/2017	Details
2,2`-(octadec-9-enylimino)bisethanol	246-807-3	25307-17-9	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	15/07/2011 15/07/2011 15/07/2011	29/08/2011 29/08/2011 29/08/2011	Details
3-chloropropyltrimethoxysilane	219-787-9	2530-87-2	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	26/08/2021 26/08/2021	11/10/2021 11/10/2021	Details
3-trimethoxysilylpropyl methacrylate	219-785-8	2530-85-0	Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): inhalation	15/04/2011 15/04/2011	30/05/2011 30/05/2011	Details
3-trimethoxysilylpropyl methacrylate	219-785-8	2530-85-0	Reproductive toxicity (pre-natal developmental toxicity)	26/04/2019	10/06/2019	Details
3-trimethoxysilylpropyl methacrylate	219-785-8	2530-85-0	Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study)	01/09/2017 01/09/2017	16/10/2017 16/10/2017	Details
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane	219-784-2	2530-83-8	Genetic toxicity in vivo	01/08/2012	17/09/2012	Details
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane	219-784-2	2530-83-8	Genetic toxicity in vivo	16/02/2015	02/04/2015	Details
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane	219-784-2	2530-83-8	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant	17/06/2020	03/08/2020	Details
Tetrapropylenebenzene	246-772-4	25265-78-5	Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	15/09/2011 15/09/2011	31/10/2011 31/10/2011	Details
Isobutyric acid, monoester with 2,2,4-trimethylpentane-1,3-diol	246-771-9	25265-77-4	Reproductive toxicity (extended one-generation reproductive toxicity study)	22/09/2022	07/11/2022	Details
Isobutyric acid, monoester with 2,2,4-trimethylpentane-1,3-diol	246-771-9	25265-77-4	Reproductive toxicity (pre-natal developmental toxicity)	16/06/2011	01/08/2011	Details
Isobutyric acid, monoester with 2,2,4-trimethylpentane-1,3-diol	246-771-9	25265-77-4	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	26/04/2019 26/04/2019 26/04/2019	10/06/2019 10/06/2019 10/06/2019	Details
Hexene	246-768-2	25264-93-1	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with Hex-1-ene (EC 209-753-1) \|\| Note: testing proposed with Octadec-1-ene (EC 112-88-9) \|\| Note: testing proposed with Hexadecene (EC 248-131-4) \|\| Note: testing proposed with Alkenes, C8-10, C9-rich (EC 271-212-0) \|\| Note: testing proposed with Nonene, branched (EC 306-492-6) Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Hex-1-ene (EC 209-753-1) \|\| Note: testing proposed with Octadec-1-ene (EC 112-88-9) \|\| Note: testing proposed with Octadecene (EC 248-205-6) \|\| Note: testing proposed with Alkenes, C8-10, C9-rich (EC 271-212-0) \|\| Note: testing proposed with Nonene, branched (EC 306-492-6)	23/11/2020 23/11/2020	07/01/2021 07/01/2021	Details
3-(trimethoxysilyl)propiononitrile	219-764-3	2526-62-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	21/03/2014 21/03/2014	05/05/2014 05/05/2014	Details
Ethylenediamine, propoxylated	500-035-6	25214-63-5	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	26/04/2019 26/04/2019	10/06/2019 10/06/2019	Details
Ethylenediamine, propoxylated	500-035-6	25214-63-5	Reproductive toxicity (extended one-generation reproductive toxicity study)\|\|Note: testing proposed with 1,1',1'',1'''-ethylenedinitrilotetrapropan-2-ol (EC no. 203-041-4) Reproductive toxicity (pre-natal developmental toxicity)	22/09/2022 22/09/2022	07/11/2022 07/11/2022	Details
2,4,4-trimethylpentene	246-690-9	25167-70-8	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: There are two testing proposals for this endpoint. Sub-chronic toxicity (90-day): oral	26/03/2018 26/03/2018	11/05/2018 11/05/2018	Details
2,4,4-trimethylpentene	246-690-9	25167-70-8	Reproductive toxicity (extended one-generation reproductive toxicity study)	15/07/2022	29/08/2022	Details
Butene	246-689-3	25167-67-3	Reproductive toxicity (extended one-generation reproductive toxicity study)\|\|Note: testing proposed with 2-methylpropene (EC no. 204-066-3) Reproductive toxicity (pre-natal developmental toxicity)\|\|Note: testing proposed with 2-methylpropene (EC no. 204-066-3) Sub-chronic toxicity (90 day): inhalation\|\|Note: testing proposed with 2-methylpropene (EC no. 204-066-3)	06/06/2023 06/06/2023 06/06/2023	21/07/2023 21/07/2023 21/07/2023	Details
[1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide	246-678-3	25155-25-3	Reproductive toxicity (pre-natal developmental toxicity)	30/11/2015	14/01/2016	Details
[1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide	246-678-3	25155-25-3	Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	06/03/2012 06/03/2012 06/03/2012	20/04/2012 20/04/2012 20/04/2012	Details
[1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide	246-678-3	25155-25-3	Reproductive toxicity (extended one-generation reproductive toxicity study)	27/05/2019	11/07/2019	Details
Trixylyl phosphate	246-677-8	25155-23-1	Bioaccumulation aquatic / sediment	02/09/2011	17/10/2011	Details
1,2,3,6-tetrahydromethyl-3,6-methanophthalic anhydride	246-644-8	25134-21-8	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	03/11/2023 03/11/2023	18/12/2023 18/12/2023	Details
tert-dodecanethiol	246-619-1	25103-58-6	Sub-chronic toxicity (90 day): inhalation	14/11/2013	30/12/2013	Details
tert-dodecanethiol	246-619-1	25103-58-6	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	22/06/2017 22/06/2017	07/08/2017 07/08/2017	Details
tert-dodecanethiol	246-619-1	25103-58-6	Long-term toxicity to fish	16/06/2022	01/08/2022	Details

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