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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 939-946-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral, LD50 = 550 mg/kg (C.I. 123.9-3930 mg/kg bw), female rat, OECD 425,
Kiss (2012)
Dermal, LD50 > 2000 mg/kg, male/female rats, OECD 402, Zelenak (2012)
Inhalation, LC50 > 1.28 mg/L, male /female Wistar strain rats, OECD 403, Nagy (2013)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 550 mg/kg bw
- Quality of whole database:
- The key study is a GLP compliant guideline study with a Klimisch score of 1.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 1 280 mg/m³ air
- Quality of whole database:
- The key study is a GLP compliant guideline study with a Klimisch score of 1.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The key study is a GLP compliant guideline study with a Klimisch score of 1.
Additional information
Unreliable screening studies which were not conducted for the purposes of REACH were discarded. Only studies conducted according to guidelines and under OECD GLP were selected as key studies for use in classification.
An acute inhalation toxicity study was conducted in accordance with OECD TG 403 (2009) and under OECD GLP. The main study group (Group 1), consisting of 10 (5 male and 5 female) CRL: (WI) Wistar strain rats was exposed to a target aerosol concentration of 1 mg/L. The animals were exposed for 4 hours using a nose-only exposure system, followed by a 14 day observation period. The day of exposure was designated Day 0. Aerosol concentrations were measured by the analytical GC method. The particle size distribution of the test aerosol was determined regularly during the exposure period. Clinical observations and bodyweights were recorded throughout the study and at the end of the scheduled period the animals were euthanised and subjected to a gross examination post mortem. Under the experimental conditions of the main study, 1/5 male and 1/5 female died in rats exposed to a mean achieved atmosphere of 1.28 mg/L for 4 hours exposure. The acute inhalation median lethal concentration of the test material in CRL: (WI) Wistar strain rats is therefore considered to be greater than 1.28 mg/L.
This inhalation study was performed for a chemical registration scheme outside of the European Economic Area. Permission to refer to the full study report is not available to the registrant, and this information is thus not provided as a robust study summary according to REACH Art. 10(a)(vi) or (vii). However, the results of the study are provided here to support the correct classification and labelling of the substance.
The data provided for this endpoint is considered to be relevant, adequate, reliable and complete for the purposes of classification and risk assessment.
Justification for classification or non-classification
An Oral LD50 of 550 mg/kg bw of the test substance means that it is a Category 4 Classification for Acute Oral Toxicity under EC no. 1272/2008 CLP criteria.
An Dermal LD50 of >2000 mg/kg bw of the test substance means that it is not classified for Acute Dermal Toxicity under EC no. 1272/2008 CLP criteria.
An Inhalation LC50 of > 1.28 mg/Lof test substance means that it is a Category 4 classification for Acute Inhalation Toxicity under EC no. 1272/2008 CLP criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.