Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Skin: Aqueous dispersion of TNS administered OECD 404. No irritation. Not classified as a skin irritant. Reliability = 1
Eye: Aqueous dispersion of TNS administered OECD 405. No irritation. Not classified as an eye irritant. Reliability = 1
Resp. tract.: Aqueous dispersion of TNS administered in a special 4-hr inhalation study in rats with histopathological evaluation, ulceration of larynx 1.0 mg a.i./m3, LOAEC 8 mg/m3, NOAEC 1 mg/m3. Not classified due to the acute toxicity classification. Reliability = 2

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

TNS is not classified for skin or eye irritation due to the observance of only mild irritation which resolved within the observation period. TNS does not need to be classified for eye or skin irritation according to the EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.

TNS was irritating to the respiratory tract of rats with a NOAEC for histopathological changes of 1 mg/m3 based on ulceration of the larynx observed at 8 mg/m3 but is not classified due to the acute toxicity classification.


Effects on respiratory irritation: highly irritating

Justification for classification or non-classification

TNS is not classified for skin or eye irritation due to the observance of only mild irritation which resolved within the observation period. TNS is not classified for respiratory tract irritation due to the acute toxicity classification.