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EC number: 605-140-1 | CAS number: 158237-07-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 22, 1995 - May 6,1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 3.6
- Temp.:
- 20 °C
- Remarks on result:
- other: pH is not mesured
Reference
Preliminary test
In a preliminary test the partition coefficient was determined to be 10 000 (H.-P.Stupp, Bayer AG, Nov. 11, 1993), log Pow = 4.0.
Partition coefficient - Summary of results
From the concentrations measured considering the dilution factor of the octanol phase the partition coefficients as the ratio of the concentrations found for octanol and for water was calculated for each run. All results were included to calculate common mean and relative standard deviation summarized at the bottom of the table below. Furthermore, the quantities of the test substance recovered by the analytical measurements were determined from the concentrations and the phase volumes. The results presented also in the table show that the recoveries are in accordance with the quantities used. It was also ascertained that the maximum concentration of test substance in either phase was in no case beyond the limit of 10~2 Mole/L given in the OECD Guidelines as the maximum concentration of the test substance. (The maximum concentration was measured in the octanol phase of run No. 4 where the molar concentrations was approx. 1 x 10-2 Mole/L).
Summary of results
Run No. |
Quantity used [mg] |
Volume of octanol [ml] |
Volume of water [ml] |
Concentration in octanol of YRC 2388 [mg/L] |
Concentration in water of YRC 2388 [mg/L] |
Quantity recovered of YRC 2388 [mg] |
Partition Coefficient |
No.1 |
347.6 |
100 |
100 |
3466 |
0.869 |
346.7 |
3988 |
No.2 |
173.7 |
100 |
100 |
1764 |
0.442 |
176.4 |
3991 |
No.3 |
86.9 |
100 |
100 |
908 |
0.232 |
90.8 |
3914 |
No.4 |
69.6 |
20 |
180 |
3539 |
0.873 |
70.8 |
4054 |
No.5 |
69.6 |
40 |
160 |
1744 |
0.451 |
69.8 |
3867 |
No.6 |
69.6 |
80 |
120 |
906 |
0.228 |
72.5 |
3974 |
mean (n= 6) |
|
3965 |
|||||
relative standard deviation |
|
1.64% |
Conclusion
The partition coefficients of test item in octanol-water was determined at 20 °C by the "shaking method" according to OECD-Guidelines No; 107 (corresponding to EEC Guidelines A8) to be 4000
(log Pow = 3.60).
Description of key information
Log Pow = 3.6 at 20 °C (OECD Guideline 107, flask method)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.6
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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