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EC number: 603-973-5 | CAS number: 136673-12-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 d
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Lithium 3[(8R,9S,10R,13S,14S,17S)-17-hydroxy-10-13-dimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetrahydrospiro[cylopenta[a]phenantrene-3,2´-[1,3]dioxolan]-17-yl]prop-2-ynoate
- EC Number:
- 603-973-5
- Cas Number:
- 136673-12-6
- Molecular formula:
- C24H31O5Li
- IUPAC Name:
- Lithium 3[(8R,9S,10R,13S,14S,17S)-17-hydroxy-10-13-dimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetrahydrospiro[cylopenta[a]phenantrene-3,2´-[1,3]dioxolan]-17-yl]prop-2-ynoate
- Test material form:
- solid: crystalline
1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- Type of inoculum: aerobic mixed bacterial culture
Source: Municipal wastewater treatment plant, Esztergom-Kertváros
Date of arriving: 03 July 2017 - Duration of test (contact time):
- 28 d
- Details on study design:
- Aerobic biodegradation of the test item was determined by measuring oxygen consumption in an inoculum containing aerobic mixed bacterial culture originated from a municipal wastewater treatment plant and maintained at laboratory conditions. The bacterial culture was not adapted to the test item.
Reference substance
- Reference substance:
- acetic acid, sodium salt
Results and discussion
- Test performance:
- This study was performed to evaluate the ready biodegradability of Prak-Li in an aerobic aqueous medium. The study was performed according to OECD 301 guideline for testing chemicals (Ready Biodegradability), method F: Manometric Respirometry [1]. Aerobic biodegradation of the test item was determined by measuring oxygen consumption in an inoculum containing aerobic mixed bacterial culture originated from a municipal wastewater treatment plant and maintained at laboratory conditions. The bacterial culture was not adapted to the test item. The Biochemical Oxygen Demand for 28 days (BOD28) of test item were determined by the manometric respiratory - OxiTop® system. Blank controls, a positive control (reference item), a toxic control and an abiotic control treatment were also included in the study. The test duration was 28 days. Sodium acetate was used as reference item.
The applied test passed all validity criteria set forth in the OECD guidelines. According to OECD guideline the test item should be classified as readily biodegradableif the percentage biodegradation reaches 60% of theoretical oxygen demand within 28 day period in a 10-day window. Based on ready biodegradability testing results the Prak-Li is not readily biodegradable.
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 2
- Remarks on result:
- other: mean of two replicates
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not inherently biodegradable
- Conclusions:
- The biodegradability of Prak-Li was investigated in Ready Biodegradability – Manometric respirometry test (according to OECD 301 F guideline).
According to OECD guideline the test item should be classified as readily biodegradable if the percentage biodegradation reaches 60% of theoretical oxygen demand within 28 day period in a 10-day window. Based on ready biodegradability testing results the Prak- Li is not readily biodegradable.
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