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EC number: 602-890-1 | CAS number: 122731-58-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Feb - Mar 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- rac-N-(2,3-Dihydroxypropyl)-5-nitroisophthalamic acid
- EC Number:
- 602-890-1
- Cas Number:
- 122731-58-2
- Molecular formula:
- C11 H12 N2 O7
- IUPAC Name:
- rac-N-(2,3-Dihydroxypropyl)-5-nitroisophthalamic acid
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Sewage plant Ruhleben
- Laboratory culture: Schering AG
The activated sewage sludge for the inoculum was collected on the day before the start of the experiment from a municipal sewage treatment plant, predominantly dealing with domestic sewage. During the time between collection and use, the sewage sludge was kept under aerobic conditions. Approximately an hour before the start of the incubation, aeration was discontinued and the sludge was allowed to sediment. The inoculum was obtained from the supernatant. - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 20 mg/L
- Based on:
- DOC
- Details on study design:
- TEST CONDITIONS
The solutions were incubated first in an incubator in darkness behind trom the 15th test day onwards on a magnetic stirrer with constant stirringin darkness. The temperature was 21 ± 1°C for 28 days.
Sampies from the test and reference solutions for an analyses were taken on days 1, 2, 5, 8, 15,22,28 and 29. The test solutions including the reference and the blank were analysed for dissolved organic carbon. For this purpose 10 mL of each solution were filtered (0.2 µm) and, subsequently, the filtrates were used for DOC-analyses. The carbon analyses were performed by injecting 20 µL of the solutions into the carbon analyser.
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 13
- Sampling time:
- 28 d
- Details on results:
- The test compound NIP-Monoamide was degraded up to 11 % on day 22 of incubation when a plateau was reached (with only slight variations thereafter). The reference compound sodium acetate was degraded to 100% on day 5 (4 days of incubation) with subsequent slight variation.
Any other information on results incl. tables
Biological degradation in % (corrected tor blank values) | ||||||||
Day of sampling | ||||||||
Test compound | 1 | 2 | 5 | 8 | 15 | 22 | 28 | 29 |
NIP-Monoamide | 0 | 4 | 7 | 6 | 7 | 11 | 10 | 13 |
Sodium acetate (reference) | 0 | 5 | 100 | 96 | 97 | 99 | 101 | 101 |
NIP-Monoamide + sodium acetate | 0 | 3 | 51 | 49 | 45 | 49 | 51 | 52 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test substance NIP-Monoamide attained only 13 % biodegradation within 28 days under the test conditions. Therefore, in accordance with the OECD guideline it can be termed as not readily biodegradable.
- Executive summary:
The purpose of this study was to determine the ready biodegradability of the test compound NIP-Monoamide (ZK 39166). The study was conducted in agreement with the test guideline of the OECD, no. 301 E "Modified OECD Screening test" for testing of chemicals; adopted 17. Jul. 92, Paris. The test substance NIP-Monoamide was incubated in aqueous solution including nutrients with microorganisms from a municipal sewage treatment plant for 28 days. The concentration of the test substance was 20 mg/L as dissolved organic carbon (DOC). The test compound was degraded up to 11 % on day 22 of incubation when a plateau was reached (with only slight variations thereafter). The reference compound sodium acetate was degraded to 100% on day 5 (4 days of incubation) with subsequent slight variation. The test substance NIP-Monoamide attained only 13 % biodegradation within 28 days under the test conditions. Therefore, in accordance with the OECD guideline, it can be termed as not readily biodegradable. The results of the toxicity control showed that the expected degradation had been reached. Therefore, no evidence of an inhibiting effect of NIP-Monoamide on the microbial population was found.
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