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EC number: 281-650-4 | CAS number: 84000-94-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Not Mutagenic
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In vitro Gene mutation study in bacteria
An ames test is on going and is expercted to be negative.
In vitro cytogenicity study in mammalian cells – Chromosomal Aberration
[Huntsman Textile Effects GmbH; 1979] – FAT Q (Similar Substance 2)
The test item dissolved in culture medium (MEM), was assessed for its potential to induce structural chromosome aberrations in the V79 cell line of the Chinese hamster, according to the OECD Guideline 473. In the absence and the presence of S9 mix the highest possible test article concentrations were evaluated. Under the test conditions no influence of the test article on the pH value or osmolarity was observed.
Nevertheless, reduced cell numbers were observed in the absence of S9 mix after continuous treatment with 5.0 ug/ml. In the presence of S9 mix no clear toxicity was observed at the highest concentration.
Neither a significant nor a biologically relevant increase in the number of cells carrying structural chromosomal aberrations was observed after treatment with the test article.
No relevant increase in the frequencies of polyploid metaphases was found after treatment with the test article as compared to the frequencies of the control.
The substance did not induce structural chromosome aberrations as determined by the chromosome aberration test in V79 cells in vitro.
In vitro gene mutation study in mammalian cells - HPRT
[Huntsman Textile Effects GmbH; 1979] – FAT I (Similar Substance 2)
The substance was tested for mutagenic effects on V79 Chinese hamster cells in vitro. The experiments were performed without microsomal activation at concentrations of 0.075, 0.15, 0.30, 0.60, 1.20, 1.80, 2.40 and 3.00 µg/ml and with microsomal activation at concentrations of 0.50, 1.00, 2.00, 4.00, 8.00, 12.00, 16.00 and 20.00 µg/ml.
With and without microsomal activation, comparison of the numbers of mutant colonies in the controls and the cultures treated with the various concentrations revealed no significant deviations
The two higest concentrations tested were too toxic and the cultures could not be subjected to the mutant selection procedure
Tthe substance and its metabolites induced no mutagenic effects in this mutation system.
Justification for selection of
genetic toxicity endpoint
The assessment of the endpoint
is performed with the integrated evaluation of results for in vitro
bacteria gene mutation, in vitro mammalian cell gene mutation assay and
in vivo micronucleus assay.
Short description of key information:
Not Mutagenic
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
According to the CLP Regulation (EC n. 1272/2008), for the purpose of classification for germ cell mutagenicity, substances are allocated to one of two categories:
CATEGORY 1
Substances known to induce heritable mutations or to be regarded as if they induce heritable mutations in the germ cells of humans.
Substances known to induce heritable mutations in the germ cells of humans.
CATEGORY 2
Substances which cause concern for humans owing to the possibility that they may induce heritable mutations in the germ cells of humans.
The classification in Category 2 is based on positive evidence obtained from experiments in mammals and/or in some cases from in vitro experiments.
Based on the experimental results and on the ECHA Guidance R7.a, Figure R.7.7-1, the substance is considered as not genotoxic and no classification for germ cell mutagenicity is warranted.
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