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EC number: 270-219-6 | CAS number: 68413-47-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 March 2004 - 24 June 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Purity: Not specified
- Description: light amber coloured, slightly viscous liquid
- Storage: room temperature, in the dark - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- Buffers
Sterile buffer solutions at pH 4, 7 and 9.
Buffer solution specifications:
- pH 4.0: Potassium hydrogen phthalate, 0.05 mmol dmE-03
- pH 7.0: Disodium hydrogen orthophosphate (anhydrous), 0.03 mmol dmE-03, Potassium dihydrogen orthophosphate, 0.02 mmol dmE-03, Sodium chloride, 0.02 mmol dmE-03
- pH 9.0: Disodium tetraborate, 0.01 mmol dmE-03, Sodium chloride, 0.02 mmol dmE-03 - Duration:
- 3.5 h
- pH:
- 4
- Temp.:
- 15 °C
- Duration:
- 5 h
- pH:
- 4
- Temp.:
- 25 °C
- Duration:
- 6 h
- pH:
- 7
- Temp.:
- 40 °C
- Duration:
- 3.5 h
- pH:
- 7
- Temp.:
- 50
- Duration:
- 6 h
- pH:
- 9
- Temp.:
- 30 °C
- Duration:
- 3.5 h
- pH:
- 9
- Temp.:
- 40 °C
- Statistical methods:
- - Sample Solution Concentration
The mean peak area of each standard was corrected to a nominal concentration of 2.0 mg/L, and the mean value taken.
The concentration of the sample solutions (g/L) was calculated using the following equation:
Cspl = (Pspl/Pstd) x Cstd x D x (1/100)
where:
Cspl: sample concentration (g/L)
Pspl: mean peak area of sample solution
Pstd: mean peak area of standard solution, corrected to nominal standard concentration
Cstd: nominal standard concentration (2.0 mg/L)
D: sample dilution factor (0.04)
- Estimation of half-life
From the graph of log10 concentration (g/L) versus time, the rate constant was calculated using the following equation:
Kobs = -slope x 2.303
The half-life was obtained from the rate constant using the following equation:
t½ = 0.693 / kobs
where:
kobs = rate constant (hours^-1)
t½ = half-life (hours) - Preliminary study:
- Preliminary testing at 50°C indicated that the test material was hydrolytically unstable, defined by the method guideline as less than 90% remaining after 120 hours at 50°C, at all thee pH’s. The results were less than 5% remaining after 2 hours at pH 4, 19.5% remaining after 5 hours at pH 7, and 8.5% remaining after 4 hours at pH 9.
- Transformation products:
- not specified
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 1.16 h
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 14.3 h
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 10.1 h
- Validity criteria fulfilled:
- yes
- Conclusions:
- The half-life of the test substance at 25°C is 1.16 hours at pH 4, 14.3 hours at pH 7, and 10.1 hours at pH 9. The test substance, thererefore, is expected to hydrolyse within the environmental compartment.
Reference
Description of key information
The half-life of the test substance at 25°C is 1.16 hours at pH 4, 14.3 hours at pH 7, and 10.1 hours at pH 9. The test substance, thererefore, is expected to hydrolyse within the environmental compartment (SafePharm, 2004).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 14.3 h
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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