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EC number: 267-499-7 | CAS number: 67874-71-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-10-24 to 2018-11-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- Three vessels were set up in a parallel design, each vessel was sampled several times instead of sampling one vessel at every point in time/ exclusion of O2 and CO2, under inert gas (argon)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- yes
- Remarks:
- Three vessels were set up in a parallel design, each vessel was sampled several times instead of sampling one vessel at every point in time/ exclusion of O2 and CO2, under inert gas (argon)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed, 2020-02-26 (inspection date: 2018-10-25)
- Type of method:
- flask method
- Specific details on test material used for the study:
- Appearance: red-brown viscous liquid
Storage Conditions: -15 °C to 40 °C - Key result
- Water solubility:
- 31.2 µg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 57.5 mg/L
- Incubation duration:
- >= 1 - <= 9 d
- Temp.:
- 20.1 °C
- pH:
- >= 4.2 - <= 4.3
- Remarks on result:
- other: S.D: ± 8.5 µg/L
- Remarks:
- Calculated on a mean dissolved bismuth concentration of 10.1 ± 2.7 µg/L and a bismuth content of 32.25 %.
- Water solubility:
- 10.1 µg/L
- Conc. based on:
- element (dissolved fraction)
- Remarks:
- Bi
- Loading of aqueous phase:
- 57.5 other: mg test item /L
- Incubation duration:
- >= 1 - <= 9 d
- Temp.:
- 20.1 °C
- pH:
- >= 4.2 - <= 4.3
- Remarks on result:
- other: S.D: ± 2.7 µg/L
- Details on results:
- - The mean temperature was 20.1 ± 0.1 °C
- The pH of test item solutions: 4.2 – 4.3
- The pH of method blank: 6.4 – 7.8
- The turbidity in samples from the test was always < 1 NTU indicating that filtered solutions did not contain any undissolved material.
- Analytical measurements: Subtraction of method blanks is not needed. The Bi concentrations in method blanks were below LOD / LOQ or far below concentrations in actual samples. The variations between the bismuth concentration measured were less than 15 % for the days 2 to 3. Since an increase of the bismuth concentration was observed between test day 1 and 3 the test was continued till day 9. The variation of bismuth concentration analysed at test day 8 and 9 were less than 15 % again and no increase was observed. Thus, the validity criteria as foreseen in OECD 105 and Regulation 440/2008/EC A.6 were fulfilled. All values measured during this test were used for calculation of the water solubility of bismuth tris(2-ethylhexanoate). The determination of the water solubility of Bismuth tris(2-ethylhexanoate) is based on mean dissolved Bi concentrations of sampling days 1, 2, 3, 8 and 9 and a bismuth amount of 32.25 % in the test item.
The bismuth concentration analysed in the triplicate test vessels vary between 7 and 12.5 µg/L (i.e., 7, 10.7 and 12.5 µg/L). This might be due to the viscosity of the test item and hence, due to a different surface area of bismuth tris(2-ethylhexanoate) which may result in different measured bismuth concentrations. - Conclusions:
- Under the conditions of this test (under exclusion of CO2 and O2, under inert gas; flask method; loadings of 51.5, 68.5 and 52.5 mg/L ultrapure water solubility equilibrium was observed during testing (day 1 – day 9). The dissolved bismuth concentration at 20.1 ± 0.1 °C is 10.1 ± 2.7 µg/L (determined as dissolved bismuth, separated by filtration from undissolved test item). This corresponds to a water solubility of bismuth tris(2-ethylhexanoate) of 31.2 ± 8.5 µg/L, calculated on a bismuth content of 32.25 %.
Reference
ICP-MS measurement with corresponding LOD/LOQ, correlation coefficient and sum of quality assurance samples and recovery.
Calibration [µg/L] – lowest and highest calibration point |
Chosen isotope and gas mode |
LOD |
LOQ |
Correlation coefficient |
Sum of quality assurance samples |
Recovery of quality assurance samples [%] |
November 08, 2018; measurement of test samples and method blanks from days 1, 2, 3 |
||||||
0.5 – 250 (total of 11 calibration points, 11 used + blank) |
209Bi in no gas mode |
0.0001 |
0.0002 |
0.9999 |
32 |
100 |
November 15, 2018; measurement of test samples and method blanks from days 8 and 9 |
||||||
0.1 – 40 (total of 10 calibration points, 10 used + blank) |
209Bi in high helium mode |
0.0002 |
0.0006 |
1.0000 |
11 |
100 |
Recovery/validation data bismuth of measurement series
Element Bi |
Recovery [%] |
SD [%] |
n (total) |
n (valid) |
November 08, 2018 |
||||
Quality control standard (Roth) 1 µg/L |
97.5 |
2.7 |
6 |
6 |
TMDA-52.4 (dilution factor 2), nominal value |
110 |
1 |
6 |
6 |
Quality control standard (Roth) 10 µg/L |
97.6 |
0.6 |
6 |
6 |
Recalibration standard 50 µg/L |
102 |
1 |
6 |
6 |
Quality control standard (Roth) 100 µg/L |
107 |
2 |
6 |
6 |
November 15, 2018 |
||||
TMDA-52.4 (dilution factor 2), nominal value |
92.9 |
2.6 |
3 |
3 |
Recalibration standard 10 µg/L |
97.2 |
2.4 |
3 |
3 |
Quality control standard (Roth) 20 µg/L |
100 |
2 |
3 |
3 |
Fortification of measurement series
Selected samples were fortified with known amounts of bismuth (by standard addition of commercial standard) to determine the standard recoveries of this element.
Sample |
Element |
Measured concentration [µg/L] |
Calculated level after addition [µg/L] |
Recovery |
November 08, 2018 |
||||
Vessel 3 sample a 1d (18AB3582, dilution 10-fold) 1 mL sample 4 mL 5 µg/L standard |
Bi |
1.02 |
4.20 |
3.92 / 93.3 |
Vessel 5 sample a 3d (18AB3618) 1 mL sample 4 mL 25 µg/L standard |
Bi |
7.42 |
21.5 |
21.8 / 101 |
November 15, 2018 |
||||
Vessel 3 sample a 8d (18AB3648) 1 mL sample 4 mL 20 µg/L standard |
Bi |
9.60 |
17.9 |
17.5 / 97.8 |
Vessel 4 sample a 9d (18AB3660) 1 mL sample 4 mL 30 µg/L standard |
Bi |
12.3 |
26.5 |
25.5 / 96.3 |
The determination of the water solubility of Bismuth tris(2-ethylhexanoate) is based on mean dissolved Bi concentrations of sampling days 1, 2, 3, 8 and 9 and a bismuth amount of 32.25 % in the test item.
Mean Bi concentrations:
Vessel 3: 10.7 ± 1.5 µg/L
Vessel 4: 12.5 ± 1.9 µg/L
Vessel 5: 7.0 ± 0.6 µg/L
Mean: 10.1 ± 2.7 µg/L
The water solubility of Bismuth tris(2-ethylhexanoate)is:
Mean of concentration x 100 % / 32.25 %:
Vessel 3: 33.1 ± 4.6 µg/L
Vessel 4: 38.8 ± 6.0 µg/L
Vessel 5: 21.6 ± 2.0 µg/L
Mean: 31.2 ± 8.5 µg/L
Calculation of water solubility according to bismuth content and 100% purity
Sample |
Bi conc. [µg/L] |
Mean Bi conc. [µg/L] |
SD [µg/L] |
mean Bi all samples [µg/L] |
SD [µg/L] |
Bi in test item [%] |
Calculated amount of test item dissolved on Basis of Bi [µg/L] |
Mean dissolved test item [µg/L] |
SD [µg/L] |
mean all samples [µg/L] |
SD [µg/L] |
vessel 3 sample a 1d |
10.2 |
10.7 |
1.5 |
10.1 |
2.7 |
32.25 |
31.59 |
33.1 |
4.6 |
31.2 |
8.5 |
vessel 3 sample b 1d |
9.77 |
30.28 |
|||||||||
vessel 3 sample a 2d |
12.0 |
37.35 |
|||||||||
vessel 3 sample b 2d |
11.5 |
35.79 |
|||||||||
vessel 3 sample a 3d |
12.8 |
39.80 |
|||||||||
vessel 3 sample b 3d |
12.7 |
39.24 |
|||||||||
vessel 3 sample a 8d |
9.60 |
29.76 |
|||||||||
vessel 3 sample b 8d |
9.62 |
29.82 |
|||||||||
vessel 3 sample a 9d |
8.41 |
26.07 |
|||||||||
vessel 3 sample b 9d |
10.1 |
31.28 |
|||||||||
vessel 4 sample a 1d |
10.4 |
12.5 |
1.9 |
32.21 |
38.8 |
6.0 |
|||||
vessel 4 sample b 1d |
9.33 |
28.94 |
|||||||||
vessel 4 sample a 2d |
11.7 |
36.29 |
|||||||||
vessel 4 sample b 2d |
15.8 |
49.07 |
|||||||||
vessel 4 sample a 3d |
14.4 |
44.70 |
|||||||||
vessel 4 sample b 3d |
14.3 |
44.27 |
|||||||||
vessel 4 sample a 8d |
12.2 |
37.97 |
|||||||||
vessel 4 sample b 8d |
12.1 |
37.52 |
|||||||||
vessel 4 sample a 9d |
12.3 |
38.06 |
|||||||||
vessel 4 sample b 9d |
12.7 |
39.38 |
|||||||||
vessel 5 sample a 1d |
5.95 |
7.0 |
0.6 |
18.44 |
21.6 |
2.0 |
|||||
vessel 5 sample b 1d |
5.92 |
18.36 |
|||||||||
vessel 5 sample a 2d |
7.34 |
22.77 |
|||||||||
vessel 5 sample b 2d |
7.19 |
22.29 |
|||||||||
vessel 5 sample a 3d |
7.42 |
23.00 |
|||||||||
vessel 5 sample b 3d |
7.84 |
24.33 |
|||||||||
vessel 5 sample a 8d |
7.13 |
22.10 |
|||||||||
vessel 5 sample b 8d |
7.39 |
22.92 |
|||||||||
vessel 5 sample a 9d |
6.70 |
20.78 |
|||||||||
vessel 5 sample b 9d |
6.83 |
21.19 |
Description of key information
Bismuth tris(2-ethylhexanoate) has a water solubility of 31.2 ± 8.5 µg/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 31.2 µg/L
- at the temperature of:
- 20 °C
Additional information
Under the conditions of this test (under exclusion of CO2 and O2, under inert gas; flask method; loadings of 51.5, 68.5 and 52.5 mg/L ultrapure water solubility equilibrium was observed during testing (day 1 – day 9). The dissolved bismuth concentration at 20.1 ± 0.1 °C is 10.1 ± 2.7 µg/L (determined as dissolved bismuth, separated by filtration from undissolved test item). This corresponds to a water solubility of bismuth tris(2-ethylhexanoate) of 31.2 ± 8.5 µg/L, calculated on a bismuth content of 32.25 %.
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