Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-875-2 | CAS number: 13530-50-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
In water aluminium orthophosphates will dissociate into their ionic forms (Al3+ and PO43-, which will further associate with the ionic forms of H2O). It is therefore considered acceptable to assess the aluminium and phosphate ions as separate entities.
The aluminium ion is considered to be toxic to fish under certain circumstances. The bioavailability and hence toxicity of aluminium is predominantly influenced by water quality parameters, in particular pH. The fate of Al3+ ion is of the most importance when considering whether a classification for aquatic toxicity of aluminium orthophosphates is required. In pH conditions of around neutral (as would be maintained via the use of appropriate buffers in a laboratory study) the Al3+ ion would be expected to react with the water molecules forming a weak acid (Al(OH)3)which would ultimately precipitate out of the water column rendering it not bioavailable and thus non-toxic to aquatic organisms. Since aluminium sulphate is soluble in water it is considered that the behaviour in water will be similar to the target substance and as such the data is relevant for assessing the toxicity of aluminium.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
The water solubility of aluminium sulphate-14-hydrate is stated as being approximately 600 g/L, therefore the solubility of aluminium tris(dihydrogen phosphate) is very similar (522 g/L) at 20±0.5°C).
3. ANALOGUE APPROACH JUSTIFICATION
On the basis of the discussion presented above the results of acute toxicity studies on aluminium sulphate-14-hydrate have been used and are justified on the basis that Al3+ ion is of concern with regards to potential toxicity and therefore the results of such a study are relevant for read-across to the target substance.
This study is submitted as part of a weight of evidence approach in accordance with REACH Annex XI, Section 1.2. When considered alongside the additional data provided for this endpoint it is considered that the ecotoxicity of the substance to be registered is adequately assessed.
4. DATA MATRIX
See full read-across justification attached under Section 13 of this dossier and summary of data included in the endpoint summary under Section 6.1 of this dossier. - Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across: supporting information
- Type:
- BCF
- Value:
- 215 dimensionless
- Basis:
- whole body w.w.
- Remarks on result:
- other: at pH 5.3
- Remarks:
- Conc.in environment / dose:200 µg/L
- Type:
- BCF
- Value:
- 123 dimensionless
- Basis:
- whole body w.w.
- Remarks on result:
- other: at pH 6.1
- Remarks:
- Conc.in environment / dose:200 µg/L
- Type:
- BCF
- Value:
- 36
- Basis:
- whole body w.w.
- Remarks on result:
- other: at pH 7.2
- Remarks:
- Conc.in environment / dose:200 µg/L
- Reported statistics:
- Statistical analyses of percent mortality (arcsine transformed values), fish weight and whole-body residues of aluminum were performed with Statistical Analysis Systems’ analysis of variance (ANOVA) programs on the mainframe computer system of the University of Missouri, Columbia, Missouri. Contrasts among means were performed by least significant difference (LSD) tests. The two compartment model of Blau et al. was used to determine the residue dynamics of aluminum in whole-body tissues of brook trout at each pH tested. The BIOFAC computer program of Blau and Agin was used to derive uptake and clearance
rate constants, biological half-lives, bioconcentration factors (BCF) and the time to 90% steady state for aluminum in whole-body tissues of brook trout.
Reference
Mean aluminum exposure concentration, whole-body residues (wet weight basis), weight and mortality
(+ standard deviations in parentheses) for brook trout exposed at acidic and neutral pH for 56 d.
Mean pH and days of exposure |
Aluminum exposure concentration [µg/L] |
Aluminum tissue concentration [µg/g] |
Weight [g] |
Mortality [%] |
pH 5.3 (0.5) |
|
|
|
|
3 |
251.5 (41.7) |
58.4 (7.6) |
0.25 (0.02) |
2.0 (0.0) |
7 |
239.0 (30.2) |
46.4 (15.8) |
0.21 (0.01) |
11.5 (3.3) |
14 |
214.0 (45.3) |
30.3 (14.3) |
0.21 (0.01) |
21.0 (2.8) |
28 |
198.1 (48.5) |
33.8 (5.6) |
0.19 (0.02) |
42.5 (13.4) |
56 |
206.8 (9.0) |
37.3 (18.0) |
0.24 (0.07) |
73.0 (16.9) |
pH 6.1 (0.3) |
|
|
|
|
3 |
323.5 (23.3) |
18.5 (6.2) |
0.26 (0.04) |
0.0 |
7 |
266.8 (68.9) |
40.7 (19.3) |
0.21 (0.03) |
0.0 |
14 |
223.5 (86.9) |
23.2 (10.1) |
0.20 (0.03) |
3.5 (0.7) |
28 |
211.9 (77.8) |
21.6 (10.9) |
0.20 (0.03) |
27.5 (12.0) |
56 |
217.1 (70.9) |
16.6 (10.3) |
0.44 (0.06) |
48.0 (33.9) |
pH 7.2 (0.1) |
|
|
|
|
3 |
415.0 (8.5) |
12.5 (1.9) |
0.27 (0.02) |
0.0 |
7 |
305.0 (127.4) |
8.3 (3.0) |
0.28 (0.03) |
0.0 |
14 |
278.2 (108.8) |
12.8 (7.1) |
0.40 (0.03) |
0.0 |
28 |
253.6 (103.1) |
9.0 (5.2) |
0.58 (0.08) |
0.0 |
56 |
261.6 (95.7) |
3.8 (0.7) |
1.50 (0.24) |
1.0 (1.4) |
The estimated time to 90% steady state for aluminum in the fish was 1.5 d at pH 5.3, 4.2 d at pH 6.1 and 1.7 d at pH 7.2. Estimated steadystate bioconcentration factors for aluminum, which were inversely related to pH, were 215 at pH 5.3, 123 at pH 6.1 and 36 at pH 7.2. The maximum observed factors were 232 at pH 5.3, 153 at pH 6.1 and 46 at pH 7.2. Brook trout eliminated aluminum from tissues more rapidly at pH 5.3 than at pH 6.1 and 7.2. Mortality was generally higher in brook trout exposed to aluminum at pH 5.3 than in those exposed at pH 6.1 and 7.2. Mortality was lowest (<3%) for the fish exposed to aluminum at pH 7.2.
Description of key information
Bioaccumulation of aluminium tris(dihydrogen phosphate) (CAS 13530-50-2) is not expected.
Key value for chemical safety assessment
Additional information
Aluminium tris(dihydrogen phosphate) (CAS 13530-50-2) is a well soluble inorganic phosphate salt and will dissociate to soluble dihydrogen phosphate (H2PO4-) in sewerage systems, sewage treatment plants and in the environment.
While BCFs indicate the potential for bioaccumulation there may be a number of complications in interpreting measured BCF values for metals and inorganic metal compounds. A general bioaccumulation assessment does not apply to phosphorus, as it is biological essential and the internal concentration will be well-regulated in living organisms.
BCFs for aluminium can be found to range from quite low to quite high values, this variance can largely be explained by the difference in exposure conditions in the different studies. An important factor influencing the bioconcentration of aluminium in fish is the water quality (e.g. pH and total organic carbon). Basically, metals do not biomagnify unless they exist in organic form. The available evidence clearly demonstrates a lack of aluminium biomagnification across several trophic levels in aquatic and terrestrial food chains respectively. Aluminium is the most abundant metallic element in the earth's crust, with a proportion of around 8% by weight, and the third most abundant of all elements. Based on its ubiquitous occurrence existing data clearly demonstrate that the present natural background concentration outweighs the anthropogenic contributions of aluminium to the environment.
Studies on the bioaccumulation potential of the aluminium tris(dihydrogen phosphate), are not available. Bioaccumulation and secondary poisoning are considered not relevant for aluminium tris(dihydrogen phosphate). The conclusion is supported by a study on the pH dependence of aluminium accumulation in brook trout (Cleveland et al. 1991). The fish were exposed to a nominal aluminium concentration of 200 µg total aluminium/L at pH values of 6.1, 3.6 and 7.2 for 56 days. The determined BCF values increased with decreasing pH and thus a pH invers dependency of aluminium accumulation in fish was demonstrated. The determined BCF values were 215 at pH 5.3, 123 at pH 6.1 and 36 at pH 7.2 respectively. During the 28-day depuration phase the aluminium elimination was more rapid at pH 5.3 than at pH 6.1 or 7.2. The biological half-life of aluminium in brook trout was 0.46 day at pH 5.3, 1.26 day at pH 6.1 and 0.52 day at pH 7.2. Though the determined BCF values increased with decreasing pH the demonstrated bioaccumulation potential of aluminium under acidic conditions is low and decreases further at neutral conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.