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Diss Factsheets
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EC number: 236-007-2 | CAS number: 13093-17-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: The oral LD50 in female Wistar rats was estimated to be greater than 2248 mg/kg bw (equivalent to 2000 mg active ingredient/kg bodyweight) in a study conducted according to OECD Guideline 420 and EU Method B.1 bis (Bradshaw, 2013).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute toxicity: oral
Bradshaw (2013) investigated the acute oral toxicity via the oral route (fixed dose method) (K1study). Following a sighting test at dose levels of 338 mg/kg and 2248 mg/kg (equivalent to 300 and 2000 mg/kg active ingredient/kg bodyweight, respectively), a further group of four fasted females was given a single oral dose of test item, as a solution in distilled water, at a dose level of 2248 mg/kg bodyweight (equivalent to 2000 mg active ingredient/kg bodyweight).
The acute oral median lethal dose (LD50) of the test item in female Wistar strain rat was estimated to be greater than 2248 mg/kg bodyweight (equivalent to 2000 mg active ingredient/kg bodyweight).
No mortality was observed. At 338 mg/kg (equivalent to 300 mg active ingredient/kg bodyweight) no signs of systemic toxicity were noted during the observation period (1 animal) . At 2248 mg/kg (equivalent to 2000 mg active ingredient/kg bodyweight) no signs of systemic toxicity were noted during the observation period of the initial treated animal.
Hunched posture was noted up to one hour after dosing in four females of the additional group and persisted up to four hours after dosing in one of these females. Noisy respiration was also noted in one animal of the additional group from four hours after dosing to day 2. The animal showed expected gains in bodyweight over the observation period. No abnormalities were noted at necropsy.
Justification for selection of acute toxicity – oral endpoint
Only one study is available for this endpoint. The LD50 is considered to be greater than 2000 mg/kg bw.
Justification for classification or non-classification
According to the available data and the criteria of the CLP and DSD Regulation, cerium tetranitrate should not be classified for acute oral toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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