Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 225-245-2 | CAS number: 4736-60-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral: LD50 (rat, m/f) >25 - <200 mg/kg bw (OECD 423/EU B.1 tris, GLP)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-01-28 to 2003-02-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 1996
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Version / remarks:
- 1996
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Version / remarks:
- June 1996
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: approx. 8 weeks
- Weight at study initiation: males 219-357 g, females 164-217 g
- Fasting period before study: Food was withheld overnight (for a maximum of 20 hours) prior to dosing until 3-4 hours after administration of the test substance.
- Housing: 3 animals/sex/cage
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +/- 3
- Humidity (%): 30-70
- Air changes (per hr): app. 15
- Photoperiod (hrs dark / hrs light): 12/12
Deviations from the maximum level for relative humidity (with a maximum of 20%) occurred which might have been caused by cleaning procedures in the room. Based on laboratory historical data these deviations were considered not to have affected the study integrity. - Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- Vehicle:
- 1% Aqueous carboxymethyl cellulose. The vehicle was selected based on trial formulations performed at study laboratory.
The formulations (w/w) were prepared within 4 hours prior to dosing. Homogeneity was accomplished to a visually acceptable Ievel. The concentration of the test substance in vehicle was varied to allow constant dosage volume in terms of ml/kg body weight.
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw - Doses:
- 25, 200 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 2000 mg/kg bw: 3 females
200 and 25 mg/kg bw: 3 per sex - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were observed for mortality twice daily. Animals were weighed on Days 1 (pre-administration), 8 and 15 and at death (if found dead after Day 1). Animals were observed for clinical signs at periodic intervals on the day of dosing (Day 1) and once daily thereafter.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, gross necropsy - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 25 - < 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The incidence of mortality was as follows, presented in chronological order of treatment:
Dose Ievel Mortality Sex
2000 mg/kg 2/3 females
200 mg/kg 1/3 females
200 mg/kg 2/3 males
25 mg/kg 0/3 males
25 mg/kg 0/3 females - Clinical signs:
- other: Clinical signs observed during the study period were as follows: Dose Ievel Clinical signs 2000 mg/kg Hunched posture, lethargy, uncoordinated movements, laboured respiration, red staining, chromodacryorrhoea 200 mg/kg
- Gross pathology:
- At macroscopic post mortem examination small and large intestines distended with gas was found among the animals that died at 2000 mg/kg and red discolouration of the glandular mucosa was found in the male that died at 200 mg/kg. Macroscopic post mortem examination of the other animals that died during the study and of the surviving animals at termination did not reveal any abnormalities.
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- Oral LD50 25-200 mg/kg bw; acute oral toxicity category 2 based on the criteria of REGULATION (EC) No 1272/2008 as well as the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 25 mg/kg bw
- Quality of whole database:
- Data from a GLP compliant guideline study with reliability 1.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an acute oral toxicity study according to OECD guideline 423, 1996, EU method B.1 tris, 1996 and US EPA Guideline OPPTS 870.1100, 1996, initially, Ethyltriphenylphosphonium iodide was administered by gavage to three female Wistar rats at 2000 mg/kg bw. In a stepwise procedure additional groups of female and male animals were dosed at 200 and 25 mg/kg bw. In the dose groups 2000, 200 and 25 mg/kg bw, 2/3, 3/6 (1/3 females, 2/3 males) and 0/6 animals died, respectively. Clinical signs observed during the study period were at dose level 2000 mg/kg bw hunched posture, lethargy, uncoordinated movements, laboured respiration, red staining and chromodacryorrhoea, at 200 mg/kg bw hunched/flat posture, uncoordinated movements, quick/slow breathing, piloerection, chromodacryorrhoea, lethargy and diarrhoea and at 25 mg/kg bw hunched posture, piloerection, lethargy and chromodacryorrhoea. The surviving animals had recovered from the symptoms between days 2 and 13. The body weight gain shown by the surviving animals over the study period was considered to be similar to that expected of normal untreated animals of the same age and strain. At macroscopic post mortem examination small and large intestines distended with gas was found among the animals that died at 2000 mg/kg bw and red discolouration of the glandular mucosa was found in the male that died at 200 mg/kg bw. Macroscopic post mortem examination of the other animals that died during the study and of the surviving animals at termination did not reveal any abnormalities.
Oral LD50 (rat, m/f) >25 - <200 mg/kg bw
In a supporting study similar to OECD guideline 401 with albino rats (strain not mentioned) an oral LD50 of 79.4 mg/kg bw (95% confidence limits 58.4 - 108 mg/kg bw) was determined.
Justification for classification or non-classification
Oral LD50 Wistar rat > 25 < 200 mg/kg bw; acute oral toxicity category 2 based on the criteria of REGULATION (EC) No 1272/2008 as well as the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations.
Ethyltriphenylphosphonium iodide is not classified for inhalative and dermal acute toxicity because of lacking data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.