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Diss Factsheets
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EC number: 209-665-3 | CAS number: 589-92-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1938
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- No details on the method used or experimental setup. Some details on sample purification provided.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no information on the method reported
- GLP compliance:
- no
- Type of method:
- other: no information reported
- Specific details on test material used for the study:
- Commercially available 4-Methylcyclohexanone was purified as follows:
4-Methylcyclohexanone was treated with a freshly prepared oversaturated filtered solution of sodium hydrogene sulfite. After shaking strongly for 3 hours the system was frozen. The next day, the solid parts were dried and washed extensively with cold ether. As soon as dried, the bisulfite derivates were decomposed with sodium carbonate. The 4-methylcyclohexanone released was rectified systematically by powerful Crismer Columns (35 spires) with external heating. - Key result
- Melting / freezing pt.:
- -40.6 °C
- Atm. press.:
- ca. 1 atm
- Conclusions:
- The fusion point for 4-Methylcyclohexanone was reported to be -40.6°C.
- Executive summary:
The fusion point for 4-Methylcyclohexanone was reported to be -40.6°C.
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1940
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- No details on sample purity. No clear details on experimental method or setup for melting/freezing point determination.
- Principles of method if other than guideline:
- Equipment used was essentially that described by Morgan ans Lowry, J. Phys. Chem., 34,2385 (1930).
Grounded capacity measurements were made with a condenser consisting of 3 parallel plates of gold-plated brass, which was immersed in the liquid. - GLP compliance:
- no
- Type of method:
- other: no detailed information was reported
- Specific details on test material used for the study:
- 4-Methylcyclohexanone supplied by Eastman Kodak Co.
- Key result
- Melting / freezing pt.:
- -41 °C
- Atm. press.:
- ca. 1 atm
- Conclusions:
- The melting point observed for 4-Methylcyclohexanone was reported as -41°C.
- Executive summary:
The melting point observed for 4-Methylcyclohexanone was reported as -41°C.
Referenceopen allclose all
The pressure of the determination was assumed by the registrant to be 1 atmosphere.
The experimental pressure was assumed by the registrant to be one atmosphere.
Description of key information
Two publications were available in the literature reporting a melting / freezing point for 4-methylcyclohexanone:
-41°C, melting point, method not reported, (White, 1940)
-40.6°C, freezing point, method not reported, (Chiurdoglu, 1938)
An additional publication which was not available reported a melting point of -42.8 °C (Sacharkin, C., Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1961, p1144). The result was not considered further.
Both primary data sources were assigned a Klimisch reliability rating of 4, due to the lack of experimental details reported in the publications. The values reported by the two independant research groups, measured on independently synthesised samples, at different times, are in very good agreement. As a result, in accordance with REACH, Annex XI, 1.2, this standard data requirement is considered to be met based on the weight of evidence. Overall the available data is considered to be adequate (all reported data is below -20°C), relevant, and sufficiently reliable, and no further testing is required for this endpoint. The value from White (1940) was taken forward for the purposes of risk assessment.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- -41 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.