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Diss Factsheets
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EC number: 209-105-8 | CAS number: 555-75-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- A mixed population of sewage treatment micro-organisms was obtained from the final effluent stage of the Severn Trent Water Plc sewage treatment plant at Loughborough, Leicestershire, UK, which treats predominantly domestic sewage.
The sample of effluent was filtered through coarse filter paper (first approximate 200 mL discarded) and maintained on aeration in a temperature controlled room at a temperature of approximately 21 °C prior to use. - Duration of test (contact time):
- 14 d
- Initial conc.:
- 100 mg/L
- Based on:
- ThOD
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Mineral salts medium as per OECD guideline
- Additional substrate: No
- Solubilising agent (type and concentration if used): NA
- Test temperature: 20 to 21°C
- pH: Ranged from 7.4 to 7.9 across all vessels
- pH adjusted: No
- Suspended solids concentration: 30 mg dry material/L
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: NA
- Number of culture flasks/concentration: Control (inoculum x 2), procedural control (refrence substance x 1), test item (x 2) and toxicity control (test and reference item x 1).
- Measuring equipment: All inoculum control, test item, procedure control and toxicity control vessels were placed in a CES Multi-Channel Aerobic Respirometer.
- Test performed in closed vessels due to significant volatility of test substance: OECD 301F utilises a closed design.
- Test performed in open system: no
SAMPLING
- Sampling frequency: Measurements made daily
- Sampling method: Automatically determined by equipment and software
- Sterility check if applicable: NA
- Sample storage before analysis: Maintained on aeration in a temperature controlled room at ca. 21°C prior to use.
CONTROL AND BLANK SYSTEM
- Inoculum blank: Yes (x 2)
- Abiotic sterile control: No
- Toxicity control: Yes (test substance and aniline)
STATISTICAL METHODS: Not applicable for study design - Reference substance:
- aniline
- Remarks:
- 100 mg/L
- Preliminary study:
- Available information indicates the test substance may hydrolyse to aluminium species and ethanol. Therefore for the purpose of this test it was considered appropriate to add the test item directly to the test vessels without the use of ultrasonication or high shear mixing.
- Test performance:
- All validity criteria were met
- Parameter:
- % degradation (O2 consumption)
- Value:
- 92
- Sampling time:
- 14 d
- Details on results:
- The difference between extremes of replicate BOD values at the end of the 10-Day window was less than 20% and therefore satisfied the validation criterion given in the OECD Test Guidelines.
The test item attained 92% biodegradation after 14 days, calculated from the oxygen consumption values, and satisfied the 10-Day window validation criterion, whereby 60% biodegradation must be attained with 10 days of the biodegradation exceeding 10%. The test item can therefore be considered to be readily biodegradable under the strict terms and conditions of OECD Guideline No. 301F.
The toxicity control attained 74% biodegradation after 14 days thereby confirming that the test item was not toxic to the sewage treatment micro-organisms used in the test. - Results with reference substance:
- Aniline (procedure control) attained 71% biodegradation after 14 days in a 10-Day Window thereby confirming the suitability of the inoculum and test conditions.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test item attained 92% biodegradation after 14 days and satisfied the 10-Day window validation criterion, whereby 60% biodegradation must be attained with 10 days of the biodegradation exceeding 10%. The test item can therefore be considered to be readily biodegradable under the strict terms and conditions of OECD Guideline No. 301F.
Reference
Percentage biodegradation values:
Day |
Biodegradation (%) |
||||
Procedure control |
Test item |
Toxicity control |
|||
R1 |
R2 |
Mean |
|||
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
1 |
3 |
2 |
0 |
3 |
0 |
28 |
38 |
33 |
7 |
4 |
7 |
52 |
60 |
56 |
16 |
5 |
35 |
69 |
74 |
72 |
23 |
6 |
56 |
77 |
81 |
79 |
27 |
7 |
61 |
82 |
84 |
83 |
33 |
8 |
63 |
85 |
86 |
86 |
39 |
9 |
66 |
86 |
87 |
87 |
44 |
10 |
67 |
87 |
88 |
88 |
50 |
11 |
69 |
88 |
90 |
89 |
58 |
12 |
70 |
88 |
91 |
90 |
69 |
13 |
70 |
89 |
91 |
90 |
73 |
14 |
71 |
91 |
92 |
92 |
74 |
Description of key information
A guideline GLP compliant ready biodegradation study is available on the substance indicating rapid degradation within 14 days.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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