Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-059-3 | CAS number: 429-60-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental starting date: 24 September 2019, Experimental completion date: 11 March 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- Trimethoxy(3,3,3-trifluoropropyl)silane
- EC Number:
- 207-059-3
- EC Name:
- Trimethoxy(3,3,3-trifluoropropyl)silane
- Cas Number:
- 429-60-7
- Molecular formula:
- C6H13F3O3Si
- IUPAC Name:
- trimethoxy(3,3,3-trifluoropropyl)silane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Identification: ST2092NM
Appearance/Physical state: clear, colourless, liquid
Batch: 802496
Purity: 100%
Expiry / Retest date: 31 October 2020
Storage conditions: room temperature, in the dark
Results and discussion
Water solubility
- Water solubility:
- <= 13.8 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 1 - <= 3 h
- Temp.:
- 20 °C
- pH:
- >= 6.7 - <= 7
- Remarks on result:
- other: potential water solubility may be higher than this but due to the hydrolytic instability of the test item a higher concentration would not persist.
Any other information on results incl. tables
Preliminary Test:
The preliminary estimate of the water solubility at 20.0 ± 0.5 °C was 13.8 mg/L. The solution had a pH of 6.2.
Definitive Test:
The concentration (g/L) of test item in the sample solutions is shown in the following table:
Sample Number |
Time Shaken at ~20 ºC (hours) |
Concentration (mg/L) |
Solution pH |
Sample blank |
n/a |
0.609 |
n/a |
1 |
1 |
11.8 |
7.0 |
2 |
2 |
0.861 |
6.7 |
3 |
3 |
1.06 |
7.0 |
Overall concentration: 11.8 g/L at 20.0 ± 0.5 ºC
Validation:
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 5 to 200 mg/L. The results were satisfactory with a correlation coefficient (r) of 1.00 being obtained.
Assessment of the sample recovery procedure was performed and proved adequate for the test; at a nominal concentration of 25 mg/L, a mean percentage recovery of 68.5% was obtained (range 67.9 to 68.8%). Test sample concentrations have not been corrected for the recovery of analysis (see Discussion).
Discussion:
On completion of the equilibration period, the samples were clear and colorless with excess test item present on the base of the test vessels. After centrifugation, the supernatants were visually observed to be clear, colorless solutions free from un-dissolved test item and had no Tyndall beam effect.
The Sponsor initially indicated that the test item was unstable in water. With knowledge of this hydrolytic instability, it was decided to reduce the shaking period of the samples. The preliminary sample was shaken at 30 °C for 3 hours and equilibrated at 20 °C for 1 hour. For the definitive test it was decided to shake the samples directly at 20 °C. The samples were extracted into hexane as the test item was stable in this solvent.
It was decided not to correct the sample results for the recovery result (68.5%) even though this was significantly lower than 100% and the individual results were consistent. This is because the loss of test item could have been mostly due to hydrolysis during sample preparation rather than incomplete extraction. As the time period the test item was in contact with water for the recoveries and test would not have been the same, a direct comparison could not be made. However, the recovery procedure does demonstrate that the majority of the test item could be recovered from an aqueous sample.
Sample 3A proved difficult to integrate among the baseline noise due to its small size. The peak was of a similar size to, possibly slight smaller than, the sample matrix blank. It was therefore decided to report the peak as a limit value based on the area of the sample matrix blank.
For the definitive test, only Sample 1 indicated a definitive presence of test item. Samples 2 and 3 were not significantly greater than the sample matrix blank. This could suggest that their shaking periods caused additional hydrolysis of the test item and that longer shaking periods would not result in a higher water solubility result. It could suggest that shaking for less than the 1 hour at 20 °C as for Sample 1 would result in a higher result. However, the test is not applicable to test items that hydrolyse that rapidly and therefore additional testing was considered not required.
The results of the preliminary test sample and Sample 1 were similar, being 13.8 mg/L and 11.8 mg/L respectively. Although the preliminary test sample was shaken at 30 °C for 3 hours, it too had a period of 1 hour at 20 °C. Given a reduced work up time, a higher result may have been possible but wouldn’t be any more meaningful given the rapid reduction in the concentration of test item due to hydrolysis. Any concentration higher than the ones measured would only persist for a very short period of time, impractically short for long term environmental considerations. Therefore being the highest measured, the preliminary test result will be used as the overall result with a caveat about stability.
As a comparison, the estimated water solubility using WSKOW v1.42 (September 2010), © 2000 U.S. Environmental Protection Agency was 8430 mg/L using its own estimated log Powof 0.73. If the partition coefficient test result of 2.81 is used, this reduces the estimated water solubility to just 140 mg/L.
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the test item has been measured up to 13.8 mg/L at 20.0 ± 0.5 °C. However, the potential water solubility may be higher than this but due to the hydrolytic instability of the test item a higher concentration would not persist. The concentration of 13.8 mg/L would also decrease over time.
- Executive summary:
The water solubility of the test item has been measured up to 13.8 mg/L at 20.0 ± 0.5 °C using the flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. However, the potential water solubility may be higher than this but due to the hydrolytic instability of the test item a higher concentration would not persist. The concentration of 13.8 mg/L would also decrease over time.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.