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Diss Factsheets
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EC number: 206-370-1 | CAS number: 333-20-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Aqueous solutions of Thiocyanates salts of ammonium, sodium or potassium, are fully dissociated. Consequently, with no specific concerns for the kations (NH4+, Na+ and K+), are studies on one of the thiocyanate substances NH4SCN, NaSCN or KSCN fully applicable for the evaluation of the other substances.
Ammonium thiocyanate was negative in the Ames test. Sodium thiocyanate is negative in an in vitro chromosome aberration study and an in vitro mammalian mutagenicity study. All studies followed adequate OECD and EU protocols and were performed under GLP. Consequently, thiocyanates are considered to be non-genotoxic.
Justification for selection of genetic toxicity endpoint
For each endpoint bacterial mutagenicity, mammalian mutagenicity and mammalian clastogenicity a GLP compliant study is available.
Short description of key information:
Ammonium thiocyanate was negative in the Ames test. Sodium thiocyanate is negative in an in vitro chromosome aberration study and an in vitro mammalian mutagenicity study. These results indicate that thiocyanates are not genotoxic.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Aqueous solutions of Thiocyanates salts of ammonium, sodium or potassium, are fully dissociated. Consequently, with no specific concerns for the kations (NH4+, Na+ and K+), are studies on one of the thiocyanate substances NH4SCN, NaSCN and KSCN fully applicable for the evaluation of the other substances.
Tests have shown these thiocyanates salts to be negative in an Ames test, in an in vitro chromosome aberration study and in an in vitro mammalian mutagenicity study. Classification for thiocyanate is therefore not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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