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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 206-370-1 | CAS number: 333-20-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Aqueous solutions of thiocyanates salts of ammonium, sodium or potassium, are fully dissociated. Consequently, results from dermal sensitisation studies with sodium thiocyanate or ammonium thiocyanate are fully applicable for the evaluation of potassium thiocyanate as well when effects are solely based on the SCN- anion.
Ammonium thiocyanate was found not to be sensitising following a maximisation test according to OECD 406. However, the study was found to be of limited validity as specifically concentrations applied for the induction phase were not high enough.
In an LLNA assay with sodium thiocyanate the SI values calculated for the substance concentrations 10, 25 and 50% were 1.6, 2.7 and 1.5 respectively. Since there was no indication that the test substance elicits an SI≥3, nor shows a dose response relation when tested up to 50%, Sodium thiocyanate was considered not to be a skin sensitizer.
Migrated from Short description of key information:
A LLNA study with NaSCN, indicates that thiocyanates are not sensitizing.
Justification for selection of skin sensitisation endpoint:
Only available study sufficient for classification purposes, based upon read-across.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
There is no information on respiratory sensitisation. However, no concerns are expected.
As chemical respiratory sensitisers also elicit positive results in predictive tests for contact sensitisation, a negative outcome for dermal sensitisation is also predictive for non respiratory sensitisation of the substance.
Additionally, the likelihood for exposure via inhalation and thus becoming sensitised to Sodium thiocyanate is very low as result to the exposure via inhalation route.The vapour pressure is extremely low (< 1.33 x 10-8 Pa) and thus does not present any potential for inhalation exposure due to volatilization of the salt. Furthermore thiocyanates are very hygroscopic (see granulometry). Inhalable particles are not available and will also not be formed during handling and use of the substance.
Migrated from Short description of key information:
As suggested in REACH guidance R7a. (R.7.3.5 Information and its sources on respiratory sensitisation), the negative results on skin sensitisation from an adequately performed appropriate test can also be regarded as lacking the potential to cause allergic sensitisation of the respiratory tract.
Justification for selection of respiratory sensitisation endpoint:
Low likelihood of exposures.
Justification for classification or non-classification
Based on the negative result from an LLNA study with sodium thiocyanate, potassium thiocyanate also need not be classified as a skin sensitizer.
As suggested in REACH guidance R7a. (R.7.3.5 Information and its sources on respiratory sensitisation), the negative results on skin sensitisation from an adequately performed appropriate test can also be regarded as lacking the potential to cause allergic sensitisation of the respiratory tract.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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