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EC number: 205-444-0 | CAS number: 140-95-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 201-03-23 to 2011-11-02
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Version / remarks:
- Homemade method to investigate complete miscibility: EM/00408/01 (chapter 4: visual method)
- Principles of method if other than guideline:
- A Pre-test according to OECD Guideline 105 was performed. In all ratios the test item was completely dissolved in the water. A complete miscibility of the test item in water was supposed. To performe the flask method described in the OECD Guideline 105, a saturated solution of the test item in water is required. Since this was not possible for this test item, a homemade method: visual method for investigation of the complete miscibility of substances, written by the test facility, was used to estimate the solubility of this test item.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: visual method
- Key result
- Water solubility:
- >= 12 - < 14 g/cm³
- Conc. based on:
- test mat.
- Incubation duration:
- > 12 - <= 72 h
- Temp.:
- 20 °C
- pH:
- >= 6.8 - <= 7.8
- Remarks on result:
- completely miscible
- Conclusions:
- The solubility (miscibility) of the test item in water at 20.0 ± 0.5 °C is ≥ 13g/100g < 14g/100g (m test item / m mixture).
- Executive summary:
Due to the impossibility of preparing a saturated solution of the test item, it was not possible to perform the test according to the OECD Guideline 105 - water solubility. A homemade method EM/00408/01, chapter 4: Visual method, was used to establish the complete miscibility of the test item. Ten mixtures with different ratios test item : water were prepared and the solubility was estimated by observations. Two of the mixtures were tested with liquid chromatography, but no certain results were observed. This may be due to the moisture-sensitivity of the test item. Therefore it was not possible to determine a more precise water solubility The water solubility based on the observations was estimated to be ≥ 13 g/ 100g < 14 g/ 100g (mtest item/ mmixture).
Reference
Pre-testing:
Mixtures of the test item with water were prepared at different concentrations. After shortly shaking by hand at room temperature (23 °C), the preparations were visually checked:
Weight of test item |
Amount of water added |
Sample size |
Observation |
108.96 mg |
10 mL |
10.9 g/L |
Completely dissolved |
502.05 mg |
10 mL |
50.2 g/L |
Completely dissolved |
1.01 g |
9.21 g |
9.9 g / 100 g |
Completely dissolved |
Thus, a complete miscibility of the test item with water was supposed.
Analytical Method:
The test item and water were mixed
in different ratios and shortly shaken by hand or agitated on a roller
mixer at room temperature (T = 23 °C) to estimate the solubility /
miscibility.
Mixtures no. 1, 4-7 and 9-10 were conditioned overnight and mixture no.
8 was conditioned over the weekend at 20.0 °C ± 0.5 °C. Mixtures no. 2
and 3 were not conditioned at 20.0 °C ± 0.5 °C. no
changes were observed with exception of mixture no. 9 (1.4 : 8.6),
where the solution was slightly turbid after conditioning.
Mixtures of the solubility test (mixtures no. 2 and 3) were analyzed applying liquid chromatography. The chromatograms showed changing ratios of the test item peaks depending on the amount of water in the mixture. This may be due to the moisture-sensitivity of the test item. Therefore it was not possible to determine the water solubility more precisely.
No. |
Weight of test item [g] |
Amount of water added [g] |
Sample size [g/100g] |
Ratio |
Observations |
pH |
1 |
1.00 |
9.00 |
10.0 |
1 : 9 |
Clear, colorless and homogeneous solution / mixture, completely dissolved / mixed after shortly shaking by hand |
6.8 |
2 |
5.03 |
5.05 |
49.9 |
1 : 1 |
Highviscous and homogeneous white mass, not completely dissolved / mixed after rolling overnight |
1) |
3 |
1.98 |
7.98 |
19.9 |
2 : 8 |
Homogeneous white liquid, not completely dissolve / mixed after rolling overnight, after standing for about one hour homogeneous solution with white bottoms |
1) |
4 |
3.12 |
7.12 |
30.5 |
3 : 7 |
Supernatant clear and colorless solution with amounts of the test item adhered to the walls and as white bottoms, not completely dissolved / mixed after rolling overnight and standing for further four days |
7.72) |
5 |
4.01 |
6.05 |
39.9 |
4 : 6 |
7.52) |
1)The measurement of the pH-value was not possible (suspension).
2)The pH of the filtrate (0.2 µm) was measured.
To determine the solubility / miscibility limits more detailed additional mixtures were prepared:
6 |
1.12 |
8.87 |
11.2 |
1.1 : 8.9 |
Clear, colorless and homogeneous solution / mixture, completely dissolved / mixed after shortly shaken by hand |
7.8 |
7 |
1.20 |
8.86 |
11.9 |
1.2 : 8.8 |
7.8 |
|
8 |
1.30 |
8.71 |
13.0 |
1.3 : 8.7 |
Clear, colorless and homogeneous solution / mixture, completely dissolved / mixed after rolling overnight |
7.5 |
9 |
1.42 |
8.64 |
14.1 |
1.4 : 8.6 |
Clear, colorless and homogeneous solution / mixture, completely dissolved / mixed after rolling overnight and additionally standing over the weekend |
7.5 |
10 |
1.61 |
8.41 |
16.1 |
1.6 : 8.4 |
Clear, colorless and homogeneous supernatant with white bottoms, not completely dissolved / mixed after rolling overnight and standing for about one hour |
7.5 |
Water used (no. 1 – 3) |
6.1 |
|||||
Water used (no. 4 – 5) |
6.3 |
|||||
Water used (no. 6 – 10) |
6.2 |
Description of key information
The solubility (miscibility) of the test item in water at 20.0 ± 0.5 °C is ≥ 13g/100g < 14g/100g (mtest item / mmixture).
Key value for chemical safety assessment
Additional information
Due to the impossibility of preparing a saturated solution of the test item, it was not possible to perform the test according to the OECD Guideline 105 - water solubility (reference 4.8-1). A homemade method EM/00408/01, chapter 4: Visual method, was used to establish the complete miscibility of the test item. Ten mixtures with different ratios test item : water were prepared and the solubility was estimated by observations. Two of the mixtures were tested with liquid chromatography, but no certain results were observed. This may be due to the moisture-sensitivity of the test item. Therefore it was not possible to determine a more precise water solubility The water solubility based on the observations was estimated to be ≥ 13 g/ 100g < 14 g/ 100g (mtest item/ mmixture).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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