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Diss Factsheets
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EC number: 204-420-7 | CAS number: 120-72-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR
- Principles of method if other than guideline:
- QSAR: Acute aquatic toxicity on Daphnia of the target chemical was estimated by using three predictors: ACD/Percepta, ECOSAR and Vega. The three predictors were employed in order to assess and combine the predictions and thus enhance the reliability of the final prediction. In the combined assessment only reliable predictions are to be taken into account.
- GLP compliance:
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 2 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Details on results:
- 48h-LC50 prediction equal to 2.0 mg/L
- Validity criteria fulfilled:
- no
- Conclusions:
- Acute aquatic toxicity on Daphnia of the target chemical was estimated by using three predictors: ACD/Percepta, ECOSAR and Vega. The three predictors were employed in order to assess and combine the predictions and thus enhance the reliability of the final prediction. In the combined assessment only reliable predictions are to be taken into account. In the case of the target Indole, the three predictors provided reliable predictions of different level of reliability. In particular, ACD/Percepta provided a moderately reliable LC50 prediction equal to 30 mg/L, ECOSAR provided a borderline reliable LC50 equal to 49.04 mg/L and Vega provided a highly reliable LC50 equal to 2.0 mg/L. Following a precautionary approach, the in silico assessment of acute aquatic toxicity on Daphnia for the target Indole was based on Vega prediction, which provided the most conservative (and most reliable) 48h-LC50 prediction equal to 2.0 mg/L. The prediction was assessed as high reliable. Considering that the predicted LC50 is close to the acute aquatic hazard classification threshold of 1 mg/L, the predicted LC50 value should be considered adequate for regulatory purposes due to the high reliability of the prediction.
- Executive summary:
Acute aquatic toxicity on Daphnia of the target chemical was estimated by using three predictors: ACD/Percepta, ECOSAR and Vega. The three predictors were employed in order to assess and combine the predictions and thus enhance the reliability of the final prediction. In the combined assessment only reliable predictions are to be taken into account. In the case of the target Indole, the three predictors provided reliable predictions of different level of reliability. In particular, ACD/Percepta provided a moderately reliable LC50 prediction equal to 30 mg/L, ECOSAR provided a borderline reliable LC50 equal to 49.04 mg/L and Vega provided a highly reliable LC50 equal to 2.0 mg/L. Following a precautionary approach, the in silico assessment of acute aquatic toxicity on Daphnia for the target Indole was based on Vega prediction, which provided the most conservative (and most reliable) 48h-LC50 prediction equal to 2.0 mg/L. The prediction was assessed as high reliable. Considering that the predicted LC50 is close to the acute aquatic hazard classification threshold of 1 mg/L, the predicted LC50 value should be considered adequate for regulatory purposes due to the high reliability of the prediction.
It should not be categorised as Aquatic toxic acut (limit 1 mg/l).
It is a readily biodegradable substance. Its log kow is 2.24. It should not be categorised as aquatic toxic chronic.
Reference
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2 mg/L
Additional information
Indole 48h-LC50 prediction equal to 2.0 mg/L (Daphnia)
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