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Diss Factsheets
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EC number: 201-166-9 | CAS number: 79-00-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity (LD50) of 1,1,2-trichloroethane is 837 mg/kg by oral administration in rats and 9 g/m3 /6hr by inhalation in rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 837 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 9 000 mg/m³ air
Additional information
For acute oral toxicity, 2 studies were available. One was with mice leading to an LD50 values of 378 mg/kg bw (White et al., 1985). The other one was conducted with rats (Smyth et al., 1969) leading to an LD50 value of 837 mg/kg bw. The LD50 obtained from the rat study was considered as the most relevant as acute studies with rats are considered as more robust or most representative of the toxicity observed in humans.
For acute dermal toxicity, no consistent results were found in the literature, and therefore this endpoint could not be definitely addressed. Two results were obtained with rabbit (Smyth et al., 1969) and Guinea pig (Wahlberg 1976), leading to an LD 50 of 5.38 g/kg bw and a LD 100 of 232 mg/cm2 respectively.
For acute inhalation toxicity, three results were obtained with mice, leading to LC 50 values of 2.3 g/m3, and LC0 of 4.42 and 2.3 g/m3, with mice exposed for 6, 3 and 4 hours, respectively. Two results were obtained with rats, leading to an LC50 of 9 g/m3 (Bonnet, 1980), with rats exposed for 6 hours and a LC60 of 2.7 g/m3, with rats exposed for 8 hours (Smyth, 1969).
The studies with rats were used for the definition of the key parameters.
Justification for classification or non-classification
Both LD50 oral values were in general agreement and result obtained with rats were considered in line with the current harmonized classification.
The acute dermal toxicity results were not considered reliable. The results for the two studies indicated a low hazard related to acute dermal toxicity. Nevertheless the current harmonized classification is not challenged.
The acute inhalation toxicity values were in general agreement. Based on the key value of 9 mg/l, classification for acute inhalation toxicity as category 3 appears more appropriate.
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