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EC number: 202-374-2 | CAS number: 94-91-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- - 40 mg of the test item was weighed into a glass flask and quantitatively transferred into a volumetric flask by multiple washing with the test medium in a total volume of 1000 mL.
- After a thorough mixing the stock mixture was not homogeneous with visible not dissolved parts of the test item.
- Therefore, the stock mixture in a tightly closed flask was sonicated with heating at 40°C for 20 min and then mixed by mechanic shaker at room temperature for 72 h.
- The homogeneous and transparent stock solution of yellow colour and characteristic odour was used as the highest test concentration and was used to prepare the lower test concentrations by sequential dilution with the test medium.
- The solutions of the test item were homogeneous, transparent of yellow colour and characteristic odour and no changes in appearance were recorded during the test. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna Straus
- Source: Institute of Industrial Organic Chemistry Branch Pszczyna, Department of Ecotoxicology, Laboratory of Aquatic Toxicology
- Age at study initiation (mean and range, SD): < 24 h old at test initiation
- Feeding during test: no
- Food type: Pseudokirchneriella subcapitata algae suspension - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 20.8 – 22.7 ºC
- pH:
- Fresh solution at exposure initiation: 7.60 - 8.15
Old solutions at renewal: 7.70 - 8.11 - Dissolved oxygen:
- Fresh solution at exposure initiation: 7.07 - 8.60
Old solutions at renewal: 7.51 - 8.30 - Nominal and measured concentrations:
- Nominal test concentrations: control, 2.5, 5, 10, 20 and 40 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beakers covered with transparent lids
- Size, fill volume: 150 mL, 50 mL
- Aeration: no
- Renewal rate of test solution: renewal of old solutions for fresh solutions after 24 h of exposure
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
OTHER TEST CONDITIONS
- Photoperiod: 16 h light : 8 h darkness - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3.162 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.77 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 2.87 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 5.034 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - In samples of fresh solutions the concentration of the test item was in the range of 80.0 – 92.8% of nominal.
- In samples of old solutions the determined concentration of the detected substance was in the range of 25.0 – 82.2% of initial.
- The concentration of the test item was not stable under test conditions. - Results with reference substance (positive control):
- The EC50 (48h) of the control substance potassium dichromate was 0.723 mg/L.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The acute toxicity of aquatic invertebrates was investigated for ‘α,α'-propylenedinitrilodi-o-cresol’ with the waterflea Daphnia magna in a GLP guideline study according to OECD 202.
After 48 hours exposure in a semi-static test system the EC50 was 3.162 mg/L based on measured test substance concentration.
Reference
Immobilization of Daphnia magna in control was 5% (allowed not more than 10%).
Oxygen concentration in the test vessels was between 7.07 – 8.60 mg/L (allowed not less than 3 mg/L).
Description of key information
Acutely toxic to aquatic invertebrates.
The acute toxicity of aquatic invertebrates was investigated with the waterflea Daphnia magnas in a GLP guideline study according to OECD 202.
After 48 hours exposure in a semi-static test
system the EC50 was 3.162 mg/l based on measured test substance concentration.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3.162 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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