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EC number: 947-879-5 | CAS number: 2475232-73-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Boiling point
Administrative data
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Version / remarks:
- 27 July 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- 4-[(2E)-3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-2-enoyl]-N-[(4R)-2-ethyl-3-oxo-1,2-oxazolidin-4-yl]-2-methylbenzamide
- EC Number:
- 947-879-5
- Cas Number:
- 2475232-73-4
- Molecular formula:
- C23H18Cl2F4N2O4
- IUPAC Name:
- 4-[(2E)-3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-2-enoyl]-N-[(4R)-2-ethyl-3-oxo-1,2-oxazolidin-4-yl]-2-methylbenzamide
- Test material form:
- solid
- Details on test material:
- Off-white
Constituent 1
Results and discussion
Boiling point
- Key result
- Atm. press.:
- 99.2 kPa
- Decomposition:
- yes
- Decomp. temp.:
- ca. 185 °C
- Remarks on result:
- not determinable
- Remarks:
- The boiling temperature could not be determined due to decomposition.
Any other information on results incl. tables
From comparison of the thermogram profiles obtained from samples analysed using pre-perforated crucible lids (which allow self-pressurisation up to the boiling temperature) and those using manually pierced crucible lids (i.e. an open system), it is possible to evaluate if an observed endotherm originates from a true boiling temperature for the test item.
However in this case, no significant endotherms (beyond the melting of the test item at approximately 170 °C) were observed before the sample underwent decomposition without any evidence of boiling, irrespective of the crucible lid type employed.
Due to the low initial rate of enthalpy change during decomposition, the onset temperature could only be approximated. Due to the variance observed, a limit value has been reported based on the lowest observed onset temperature.
The use of manually pierced crucibles (an open system) also provided an opportunity to assess the stability of the test item in air and in an inert atmosphere (nitrogen). Decomposition was observed both in air and under a nitrogen atmosphere, indicating the process was most likely thermal and not oxidative.
Applicant's summary and conclusion
- Conclusions:
- The substances started to decompose at about 185 °C at a pressure of 99.2 kPa. The boiling temperature could therefore not be determined.
- Executive summary:
The boiling temperature of the substance was investigated under GLP to OECD TG 103 by using differential scanning calorimetry. The temperature accuracy of the instrument was tested with indium and zinc before the start of the test and found to be acceptable. Aliquots of test substance of about 0.005 g were placed in aluminium crucibles with pre-forated or manually pierced lids and these were placed in the instrument, which was then heated from 20 °C to up to 450 °C at a rate of 20 °C/minute. The first four determinations were done under static air atmosphere (two with pre-perforated and two with manually pierced lids), while the last two determinations were done under nitrogen atmosphere (using manually pierced lids). No significant endotherms (beyond the melting of the test subtance at about 170 °C) were observed in the thermograms, before the substance underwent decomposition without any evidence of boiling, irrespective of the crucible lid type employed. Due to the low initial rate of enthalpy change during decomposition, the onset temperature could only be approximated. Due to the variance observed, a limit value has been reported based on the lowest observed onset temperature. Decomposition was observed both in air and under a nitrogen atmosphere, indicating the process was most likely thermal and not oxidative. The test substance was determined to decompose from approximately 185 °C onwards at a pressure of 99.2 kPa, without any evidence of boiling.
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