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EC number: 202-594-9 | CAS number: 97-61-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pre-guideline study. Similar to guideline. Non-fasted animals.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 954
- Report date:
- 1954
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Screening method
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methylvaleric acid
- EC Number:
- 202-594-9
- EC Name:
- 2-methylvaleric acid
- Cas Number:
- 97-61-0
- Molecular formula:
- C6H12O2
- IUPAC Name:
- 2-methylpentanoic acid
- Details on test material:
- 2-Methylpentanoic acid [CAS No. 97-61-0], not further specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: raised in own colony
- Weight at study initiation: 90 to 120 g
- Fasting period before study: no
- Diet: complete rat diet ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: water, corn oil, or 1% solution Tergitol Penetrant 7 (sodium 3,9-diethyl-6-tridecanol sulfate)
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): dose volume 1 to 10 mL/kg bw
- Justification for choice of vehicle: dilution of neat substance
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw - Doses:
- no data
- No. of animals per sex per dose:
- 5 males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: no data - Statistics:
- LD50 value was calculated uisngteh method of Thompson (1947) and Weil (1952)
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 040 mg/kg bw
- 95% CL:
- 1 820 - 2 270
Any other information on results incl. tables
Fiducial range of LD50 values (+-1.96 S.D.) was from 1820 - 2270 mg/kg.
Applicant's summary and conclusion
- Conclusions:
- The oral LD50-value in rats was 2040 mg/kg bw.
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