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EC number: 284-510-0 | CAS number: 84929-26-0 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Commiphora myrrha, Burseraceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- On going study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442B (Skin Sensitization: Local Lymph Node Assay: BrdU-ELISA)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA): BrdU-ELISA
Test material
- Reference substance name:
- Commiphora myrrha, ext.
- EC Number:
- 284-510-0
- EC Name:
- Commiphora myrrha, ext.
- Cas Number:
- 84929-26-0
- Molecular formula:
- Not relevant, UVCB substance
- IUPAC Name:
- Commiphora myrrha, ext.
- Test material form:
- liquid
- Details on test material:
- Storage room temperature
CAS N°18016-37-31
EC N° 284-510-0
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- other: CBA/J (CBA/JRj)
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Elevage Janvier Labs, Le Genest-Saint-Isle, France.
- Age at study initiation: 8 weeks
- Weight at study initiation: 20.2-23.8 g
- Housing: Animals were individually housed in suspended solid-floor polypropylene cages furnished with softwood wood flakes.
- Diet: Teklad Global 16% Protein Rodent Diet (Envigo, 2016), ad libitum
- Water: Drinking water (tap water from public distribution system), ad libitum
- Acclimation period: at least5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 19-25 °C
- Humidity: 30-70 %
- Air changes: 10 changes/h
- Photoperiod: 12 h dark / 12 h light
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- On going study
- No. of animals per dose:
- On going study
- Details on study design:
- Day 1
The weight of each animal is recorded and the thickness of the right ear of each animal of the vehicle control and treated groups is measured using a micrometer.
Open application of 25 µL of the appropriate dilution of the test item, the vehicle alone, or the positive control (as appropriate), are done to the dorsum of each ear. The test item is spread over the entire dorsal of the ear using the tip of the micropipette.
• GROUP 1 (Negative control): 25 µL of the vehicle
• GROUP 2 (Treated): 25 µL of the appropriate dilution of the test item (low concentration).
• GROUP 3 (Treated): 25 µL of the appropriate dilution of the test item (medium concentration).
• GROUP 4 (Treated): 25 µL of the appropriate dilution of the test item (high concentration).
Day 2
The application procedure carried out on day 1 is repeated.
Day 3
The thickness of the right ear is measured and then the application procedure carried out on day 1 is repeated.
Day 4
No treatment.
Day 5
0.5 mL (5 mg/mouse) of BrdU (10 mg/mL) solution is injected intra -peritoneally
Day 6
The weight of each animal is recorded.
Approximately 24 hours (24 h) after BrdU injection, the mice are sacrificed with an intraperitoneal injection of sodium pentobarbital (Dolethal®).
The thickness of the right ear of each animal of the vehicle control and treated groups is measured using a micrometer and punch biopsies of 8 mm in diameter. The apical area of both ears is prepared and weighed in order to assess the irritation potential of the test item.
For each individual animal of each group the draining auricular lymph nodes are excised. - Statistics:
- No data
Results and discussion
- Positive control results:
- On going studies
In vivo (LLNA)
Resultsopen allclose all
- Key result
- Parameter:
- other: EC1.6
- Remarks on result:
- other: on-going
- Key result
- Parameter:
- SI
- Variability:
- To be performed
- Test group / Remarks:
- To be performed
- Remarks on result:
- other: on-going
- Key result
- Parameter:
- SI
- Variability:
- To be performed
- Test group / Remarks:
- To be performed
- Remarks on result:
- not measured/tested
- Parameter:
- SI
- Variability:
- To be performed
- Test group / Remarks:
- To be performed
- Remarks on result:
- other: on-going
Any other information on results incl. tables
Study on-going
Applicant's summary and conclusion
- Interpretation of results:
- other: Study on-going
- Conclusions:
- Study on-going
- Executive summary:
Study on-going
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