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Diss Factsheets
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EC number: 203-728-9 | CAS number: 110-01-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-4 (Acute Eye Irritation)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tetrahydrothiophene
- EC Number:
- 203-728-9
- EC Name:
- Tetrahydrothiophene
- Cas Number:
- 110-01-0
- Molecular formula:
- C4H8S
- IUPAC Name:
- tetrahydrothiophene
- Details on test material:
- Source: Pennwalt Corporation
Batch: 113-539-84
Purity: no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Hazleton-Dutchland, Inc.3 , Denver, PA
- Age at study initiation: young adults
- Weight at study initiation: no data
- Housing: individually
- Diet (e.g. ad libitum): Lab Rabbit Chow HF (Purina #5326)
- Water (e.g. ad libitum): tap water
- Acclimation period: 20 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 60-70
- Humidity (%): 30-70
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Amount applied: 0.1 ml
- Duration of treatment / exposure:
- The appropriate amount of the test material was introduced into the lower conjunctival sac of the right eye of each animal. The upper and lower lids were gently held together for one second prior to releasing to prevent loss of material. The contralateral eye served as the control.
No wash was performed after application of the material. However, approximately 24 hours after application, the treated eye was rinsed to remove any residual test material. - Observation period (in vivo):
- - Intervals:
Approximately 1, 24, 48 and 72 hours and 7 and 10 days after treatment, or until no signs of irritation were present.
- Method:
At interval the treated and control eyes were examined and scored for ocular reactions according to the Draize scale. Fluorescein dye was used to confirm presence or absence of corneal ulceration in treated eyes starting with the 24 hour observation and at each subsequent observation until there was no stain retention for two observations. Unusual effects such as pannus, blistering of the conjunctiva, ulceration and other effects indicative of corrosive action were also noted when present. - Number of animals or in vitro replicates:
- 6
- Details on study design:
- Preparation of Animals:
On the day before dosing, both eyes of each animal were examined using fluorescein dye to check for presence of corneal ulceration. Just prior to test substance application, the eyes were examined again, but without fluorescein. Animals showing pre-existing corneal or conjunctival injury or irritation were not placed on study.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 + 48 + 72 h
- Score:
- 2.27
- Max. score:
- 3
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 + 48 + 72 h
- Score:
- 1.16
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24 + 48 + 72 h
- Score:
- 0.11
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 + 48 + 72 h
- Score:
- 0.55
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- Tetrahydrothiophene produced moderate to severe but reversible ocular irritation. All six animals exhibited severe conjunctival irritation (redness, chemosis, discharge, necrosis) and iritis and three exhibited corneal opacity and ulceration. Three animals were noted to have hair loss around the eye. The most severe conjunctival and iridial effects occurred one hour after instillation of the test material and corneal effects were most severe at 24 hours. Recovery was apparent, however, and all six animals were free of ocular irritation within 7 to 10 days after instillation of the test material.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2A (irritating to eyes) based on GHS criteria
- Conclusions:
- A transient conjunctivitis and/or corneal opacity are observed after acute instillation in the eye of rabbits.
- Executive summary:
In a study performed according to EPA guideline #OPP 81-4 and GLP, 0.1 ml of Tetrahydrothiophene was instillated in the conjunctival sac of 6 rabbits. Eye reactions were evalutated 1, 24, 48, 72 hours and 7 and 10 days after the initial administration. No wash was performed after application of the material.
Tetrahydrothiophene produced moderate to severe but reversible ocular irritation. All six animals exhibited severe conjunctival irritation (redness, chemosis, discharge, necrosis) and iritis and three exhibited corneal opacity and ulceration. Three animals were noted to have hair loss around the eye. The most severe conjunctival and iridial effects occurred one hour after instillation of the test material and corneal effects were most severe at 24 hours. Recovery was apparent, however, and all six animals were free of ocular irritation within 7 to 10 days after instillation of the test material. Mean scores over 24, 48 and 72h were 2.27, 1.16, 0.11 and 0.55 for conjunctival redness and chemosis, iritis and corneal opacity, respectively.
According to these results, tetrahydrothiophene should be considered as irritant for the eyes.
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