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Diss Factsheets
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EC number: 203-728-9 | CAS number: 110-01-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The data available on tetrahydrothiophene and the estimations from its physico-chemical properties indicate a significant absorption by inhalation exposure, a very low rate of dermal absorption, widespread distribution, rapid metabolism by oxidation of the sulphide functions and no bioaccumulation potential of parent and transformation products.
The absorption/excretion, toxicokinetics, metabolism and distribution data of tetrahydrothiophene were evaluated from the available toxicological data and the physicochemical properties as suggested by the REACH Guidance Chapter R.7c:
Molecular weight: 88.17 g/mol
Water solubility: 5800 mg/L
Partition coefficient log Kow = 1.8
Vapor pressure : 2400 Pa @25°C
ABSORPTION
Inhalation route
According to the REACH Guidance, the physicochemical characteristics of tetrahydrothiophene (log Pow 1.8) and the molecular mass (88.17 g/mol) are in a range suggestive of absorption as such from the respiratory subsequent to inhalation exposure. This assumption of absorption is confirmed by the mortality and clinical signs observed in the acute inhalation toxicity study (Terril, 1986). Therefore, a default inhalation absorption rate of 50% will be used for risk assessment.
Dermal absorption
The rate of absorption of tetrahydrothiophene was estimated using the IH SkinPerm model using a Kp derived from the EPI Dermwin model. The fraction of dose absorbed was 0.00383% for an instantaneous deposition and 0.00747% for a deposition over time. Therefore, a default skin absorption rate of 1% will be used for tetrahydrothiophene.
DISTRIBUTION and METABOLISM
According to the REACH Guidance, as a small molecule a wide distribution of tetrahydrothiophene propane is expected.
According to the limited information available, the metabolism of tetrahydrothiophene involves extensive oxidation. Tetrahydrothiophene-1,1-dioxide is formed from the sulfide, and this is then further metabolized to 3-hydroxytetrahydrothiophene-1,1-dioxide. Up to 85% of the ip administered dose is excreted in the urine within 24 hours (Roberts and Warwick, 1961).
In another limited study, two mice were each given a single intraperitoneal injection of 200 µl of a 0.9% sodium chloride solution containing 25 µCi [methyl-3H] methionine plus 25 mM tetrahydrothiophene, equivalent to 250 µmol/kg body weight (ca. 22 mg/kg body weight). In 1 mouse, 17.7 x 10e-3 cpm methyl sulfonium derivatives/g were found in the liver, while the corresponding figures for the lungs and the kidneys were 3.0 and 6.0 x 10e-3 cpm/g, respectively. The other mouse was kept in a metabolism cage. The 24-hour urine contained 19.3 x 10e-3 cpm/ml. The authors thus considered that in vivo, tetrahydrothiophene was metabolized to methyl sulfonium derivatives, which were then excreted in the urine (Mozier and Hoffman, 1990).
ELIMINATION
According to the REACH Guidance, the n-Octanol/water partition coefficient (log Pow of 1.83) and the metabolism is not suggestive of accumulation of unchanged tetrahydrothiophene in fatty tissues subsequent to absorption. Therefore, no potential for bioaccumulation is to be expected for tetrahydrothiophene.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 1
- Absorption rate - inhalation (%):
- 50
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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