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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 932-833-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 25 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 1 252.85 mg/m³
- Explanation for the modification of the dose descriptor starting point:
DNEL for systemic effects via the inhalation route is derived from a rat oral subchronic toxicity study for ammonium sulfate (CAS 7783-20-2) in which the NOAEL was 256 mg/kg bw/day. Based on the knowledge that 36% of the registered substance is ammonium sulfate, the equivalent NOAEL for the reaction mass of ammonium iron (III) citrate was calculated to be 711 mg/kg bw. Correction for respiratory rate and volume (rat to human worker): (6.7m3/d/10m3/d)*(1/0.38) (default). Therefore the corrected NOAEC for repeated-dose systemic effects via the inhalation route is [711 mg/m3*(6.7m3/d/10m3/d)*(1/0.38)] = 25 mg/m3
- AF for dose response relationship:
- 1
- Justification:
- The starting point is the NOAEL above which chronic nephropathy was present.
- AF for differences in duration of exposure:
- 2
- Justification:
- Default for sub-chronic to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Not required for inhalation route
- AF for other interspecies differences:
- 2.5
- Justification:
- Default
- AF for intraspecies differences:
- 5
- Justification:
- Default
- AF for the quality of the whole database:
- 1
- Justification:
- Good quality guideline study
- AF for remaining uncertainties:
- 2
- Justification:
- Oral to inhalation; higher absorption
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 7.1 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 711 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
DNEL for systemic effects via the dermal route is derived from a rat oral subchronic toxicity study for ammonium sulfate (CAS 7783-20-2) in which the NOAEL was 256 mg/kg bw/day. Based on the knowledge that 36% of the registered substance is ammonium sulfate, the equivalent NOAEL for the reaction mass of ammonium iron (III) citrate was calculated to be 711 mg/kg bw. Therefore the starting NOAEL for repeated-dose systemic effects via the dermal route is 711 mg/kg bw/day.
- AF for dose response relationship:
- 1
- Justification:
- The starting point is the NOAEL above which chronic nephropathy was present.
- AF for differences in duration of exposure:
- 2
- Justification:
- Default for sub-chronic to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default
- AF for other interspecies differences:
- 2.5
- Justification:
- Default
- AF for intraspecies differences:
- 5
- Justification:
- Default
- AF for the quality of the whole database:
- 1
- Justification:
- Good quality guideline study
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Data from long term studies was available for assessment for both ammonium sulfate (CAS 7783-20-2) and ferric trichloride (CAS 7705-08-0). Based on the known composition of the registered substance, the original NOAELs were used to calculate DNELs expressed as the reaction mass of ammonium iron (III) citrate and ammonium sulfate. As a cautionary approach, the lowest DNELs were then selected and presented as the basis for exposure assessment, which originate from data on ammonium sulfate.
However for completeness, information for ferric trichloride is included as follows:
A 90 day oral study in rat for ferric trichloride was available for assessment which reports a NOAEL of 277 mg/kg bw/day, equivalent to 94.18 mg/kg bw/day expressed as iron. Based on the known composition of the registered substance of 12.2% iron, the NOAEL expressed as the reaction mass of ammonium iron (III) citrate and ammonium sulfate is 771.96 mg/kg bw/day. Based on the same overall assessment factors reported and used for derivation of the current DNELs (based on ammonium sulfate), the respective DNELs derived for ferric trichloride are as follows: 7.7 mg/kg (repeated-dose – systemic – dermal - worker), and 27 mg//m3 (repeated-dose – systemic – inhalation - worker).
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.6 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 711 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
DNEL for systemic effects via the oral route is derived from a rat oral subchronic toxicity study for ammonium sulfate (CAS 7783-20-2) in which the NOAEL was 256 mg/kg bw/day. Based on the knowledge that 36% of the registered substance is ammonium sulfate, the equivalent NOAEL for the reaction mass of ammonium iron (III) citrate was calculated to be 711 mg/kg bw. Therefore the starting NOAEL for repeated-dose systemic effects via the oral route is 711 mg/kg bw/day.
- AF for dose response relationship:
- 1
- Justification:
- The starting point is the NOAEL above which chronic nephropathy was present.
- AF for differences in duration of exposure:
- 2
- Justification:
- Default for subchronic to chronic.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default.
- AF for other interspecies differences:
- 2.5
- Justification:
- Default.
- AF for intraspecies differences:
- 10
- Justification:
- Default.
- AF for the quality of the whole database:
- 1
- Justification:
- Good quality guideline study.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Data from long term studies was available for assessment for both ammonium sulfate (CAS 7783-20-2) and ferric trichloride (CAS 7705-08-0). Based on the known composition of the registered substance, the original NOAELs were used to calculate DNELs expressed as the reaction mass of ammonium iron (III) citrate and ammonium sulfate. As a cautionary approach, the lowest DNELs were then selected and presented as the basis for exposure assessment, which originate from data on ammonium sulfate.
However for completeness, information for ferric trichloride is included as follows:
A 90 day oral study in rat for ferric trichloride was available for assessment which reports a NOAEL of 277 mg/kg bw/day, equivalent to 94.18 mg/kg bw/day expressed as iron. Based on the known composition of the registered substance of 12.2% iron, the NOAEL expressed as the reaction mass of ammonium iron (III) citrate and ammonium sulfate is 771.96 mg/kg bw/day. Based on the same overall assessment factors reported and used for derivation of the current DNELs (based on ammonium sulfate), the respective DNEL derived for ferric trichloride is: 3.9 mg/kg (repeated-dose – systemic – oral - general population).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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