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EC number: 202-853-6 | CAS number: 100-44-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Few details on the materials and methods are available and examinations results are not specifically described for benzyl chloride. This study should therefore be considered as not assignable due to insufficient documentation.
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative toxicity of chloride derivatives of toluene: benzyl chloride, benzal chloride and benzotrichloride
- Author:
- Mikhailova T.V.
- Year:
- 1 964
- Bibliographic source:
- Gigiena Truda i Professional'nye Zabolevaniya, 8, 9, 14-19.
Materials and methods
- Principles of method if other than guideline:
- Animals (white mice and rats) were subjected to inhalational poisoning for 2hour in a 100-liter chamber (static method). Lethality, clinical signs and pathological changes were followed to assess poisoning after two weeks exposure in mice and one month in rats. A first experiment allowed the determination of LC50, and then a second experiment was conducted to establish a qualitative difference between the three tested substance benzyl chloride, benzotrichloride and benzal chloride.
- GLP compliance:
- not specified
- Test type:
- other: static method
- Limit test:
- no
Test material
- Reference substance name:
- α-chlorotoluene
- EC Number:
- 202-853-6
- EC Name:
- α-chlorotoluene
- Cas Number:
- 100-44-7
- Molecular formula:
- C7H7Cl
- IUPAC Name:
- (chloromethyl)benzene
- Reference substance name:
- chloromethylbenzene
- IUPAC Name:
- chloromethylbenzene
- Details on test material:
- No data
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: no data
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- spectrophotometry
- Duration of exposure:
- 2 h
- Concentrations:
- No data for the first experiment but 0.1 mg/L was tested in the second experiment
- No. of animals per sex per dose:
- In the first set of experiment unknown, in the second, ten animals per dose (0.1 mg/L)
- Control animals:
- other: yes in the second experiment, no data for the first
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 0.74 mg/L air
- 95% CL:
- >= 0.5 - <= 1.1
- Exp. duration:
- 2 h
- Remarks on result:
- other: for rats
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 0.39 mg/L air
- 95% CL:
- >= 0.26 - <= 0.58
- Exp. duration:
- 2 h
- Remarks on result:
- other: for white mice
Any other information on results incl. tables
Toxicological symptoms were excitation and irritation of conjunctiva and mucosal membranes of the respiratory tract. Furthermore hyperaemia of tail, ears and pads were noticed.
Histopathological examination revealed inflammation of the respiratory tract accompanied by bacterial superinfection, fat distrophy in liver cells, epithelial necrosis of renal tubules, distrophic alterations of the cardiac muscle and cortical cell swelling in CNS.
In the second experiment, more clinical signs were monitored and pathological changes were greater.
Applicant's summary and conclusion
- Interpretation of results:
- very toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In the test conditions, the authors tested the inhalational poisoning of rats and white mice exposed two hours by benzyl chloride (CAS n° 98-07-7) by following lethality, clinical signs and pathological changes. They estimated a LC 50 of 0.74 mg/L and 0.39 mg/L for rats and white mice respectively.
At this level of information, benzyl chloride should be classfied as toxic by inhalation or toxicant category 2 according to the 67/548/EC regulation and the CLP regulation n°1272/2008/EC respectively by applying default values of the Haber's law. - Executive summary:
In the test conditions, the authors tested the inhalational poisoning of rats and white mice exposed two hours by benzyl chloride (CAS n° 98 -07 -7) in 100 -liter chamber with a static method. The exposure concentration in the inhalation chamber was assessed by spectrophotometry. The authors followed lethality, clinical signs and pathological changes in mice and rats exposed to the test substance over a period of two weeks or fours weeks respectively.
They estimated a LC 50 of 0.39 mg/L and 0.74 mg/L for white mice and rats respectively. They confirmed their results with a second poisoning experiment where they looked qualitatively in the same test conditions at clinical and pathological responses into rats and white mice exposed to 0.1 mg/L benzyl chloride.
At this level of information, benzyl chloride should be classfied as toxic by inhalation or a toxicant category 2 according to the 67/548/EC regulation and the CLP regulation n°1272/2008/EC respectively by applying default values of the Haber's law. Indeed, LC 50 (4h) could be estimated with a time weight average rule. It would result in a LC 50 (4h) of 0,37 mg/L for rats. Assuming the test solution to be a mist, benzyl chloride should then be classified as proposed.
However, since few details on the materials and methods are known (as precise route of exposure and doses), as the process for generation of inhalative test substance is unknown and since specific results for benzyl chloride are not enough described. This study should be considered as not assignable due to insufficient documentation.
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