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Diss Factsheets
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EC number: 500-002-6 | CAS number: 9002-92-0 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two toxicity to micro-organism studies as-
2. and 3. - GLP compliance:
- not specified
- Analytical monitoring:
- no
- Remarks:
- 2. no data available, 3. no
- Vehicle:
- not specified
- Test organisms (species):
- activated sludge
- Details on inoculum:
- 2.
- Concentration: 1527 mg/l
3.
- Laboratory culture: Test organism municipal activated sludge was obtained from laboratory wastewater treatment plant. - Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 30 min
- Dose descriptor:
- EC50
- Effect conc.:
- 140 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: 2.
- Duration:
- 30 min
- Dose descriptor:
- other: EC20
- Effect conc.:
- 750 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: 3.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value was determined to be 140 mg/l.
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxic effect of the test chemical on micro-organisms.The studies are as mentioned below:
Toxicity to activated sludge study was carried out. The study was performed according to EC Guideline 88/302/EC. Inoculum conc. used for the study was 1527 mg/l. On the basis of the effect of test chemical on respiration of the test organism activated sludge, the EC50 value was determined to be 140 mg/l.
Another toxicity to activated sludge study was carried out for 30 mins. The study was performed in accordance with the OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test. Test chemical concentration was not verified analytically. On the basis of the effect of test chemical on respiration of the test organism activated sludge, the 30 mins EC20 value was determined to be 750 mg/l.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value was determined to be 140 mg/l.
Reference
Description of key information
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value was determined to be 140 mg/l.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 140 mg/L
Additional information
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxic effect of the test chemical on micro-organisms.The studies are as mentioned below:
Toxicity to activated sludge study was carried out. The study was performed according to EC Guideline 88/302/EC. Inoculum conc. used for the study was 1527 mg/l. On the basis of the effect of test chemical on respiration of the test organism activated sludge, the EC50 value was determined to be 140 mg/l.
Another toxicity to activated sludge study was carried out for 30 mins. The study was performed in accordance with the OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test. Test chemical concentration was not verified analytically. On the basis of the effect of test chemical on respiration of the test organism activated sludge, the 30 mins EC20 value was determined to be 750 mg/l.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value was determined to be 140 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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