Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 947-354-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity study in female Wistar rats (Up/Down procedure)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- up-and-down procedure
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Age/Weight at dosing : 9 to 11 weeks, Weight (g) Minimum: 167.0, Maximum: 174.1
Source : Animal Breeding Facility, Jai Research Foundation
Total Number of Animals Used : Five females (nulliparous and non-pregnant) - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Single oral exposure
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- This study was conducted as a limit study with the dose level of 2000 mg a.i./kg body weight. The first rat was given a single dose of 2000 mg a.i. Methacryloxyisopropyl Acid Phthalate/kg body weight. No mortality was observed at this dose level up to 48 h post dosing. Therefore, rat N° 2, 3, 4 and 5 were treated with the same dose level of 2000 mg a.i. Methacryloxyisopropyl Acid Phthalate/kg body weight, one at a time, separated by minimum 48 h intervals. All rats survived at the dose level of 2000 mg a.i. Methacryloxyisopropyl Acid Phthalate/kg body weight, the end point was achieved and further testing was not required
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- None
- Clinical signs:
- No clinical signs
- Body weight:
- no BW observations
- Gross pathology:
- No abnormalities
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 was estimated to be greater than 2000 mg a.i. Methacryloxyisopropyl Acid Phthalate/kg body weight in female Wistar rats.
- Executive summary:
An acute oral toxicity study (Up-and-Down Procedure) was conducted using five female Wistar rats given a single oral dose of Methacryloxyisopropyl Acid Phthalate (Undiluted, as received). A limit Test was conducted with 2000 mg a.i./kg body weight. Doses were corrected for the purity of the material. The first rat survived; hence the four additional female Wistar rats each received a single dose of 2000 mg a.i./kg body weight according to the Up-and-Down Procedure.
No sign of toxicity was observed in the rats treated with theMethacryloxyisopropyl Acid Phthalateat 2000 mg a.i./Kg body weight.
All rats were active and healthy during the study. All rats gained body weight by the end of the study period.
External and visceral examination of terminally sacrificed rats did not reveal any lesions of pathological significance. In absence of any pathological lesion in terminally sacrificed animals, it is concluded that the test item did not produce any treatment related effect at the dose level used in the present study.
The acute oral estimated LD50of the Methacryloxyisopropyl Acid Phthalate was estimated to be greater than 2000 mg a.i./kg body weight in female Wistar rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Good
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Not classified
In the Acute oral toxicity study in femal wistar rats, no mortality and signs of toxicity were observed at 2000 mg a.i./kg bw/day. Therefore the LD50 is estimated to be > than 2000 mg/kg bw/day and the criteria for classification are not met.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.