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EC number: 224-403-8 | CAS number: 4345-03-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Remarks:
- estimated
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Method in accordance to REACH guidance on QSARs: Chapter R.6. QSARs and grouping of chemicals
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs: Chapter R.6. QSARs and grouping of chemicals
- Deviations:
- no
- Principles of method if other than guideline:
- EPI SUITE (BIOWIN v4.11)
- Specific details on test material used for the study:
- α - tocopheryl hydrogen succinate
CAS: 4345-03-3
SMILES: CC1=C2C(=C(C(=C1C)OC(=O)CCC(=O)O)C)CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C
MW: 530.78 - Oxygen conditions:
- other: not applicable
- Inoculum or test system:
- other: not applicable
- Key result
- Parameter:
- half-life in days (QSAR/QSPR)
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Details on results:
- Probability of Rapid Biodegradation (BIOWIN v4.11):
Biowin1 (Linear Model): 0.9084
Biowin2 (Non-Linear Model): 0.9538
Expert Survey Biodegradation Results:
Biowin3 (Ultimate Survey Model): 1.9614 (months)
Biowin4 (Primary Survey Model) : 3.3460 (days-weeks)
MITI Biodegradation Probability:
Biowin5 (MITI Linear Model): 0.4028
Biowin6 (MITI Non-Linear Model): 0.1257
Anaerobic Biodegradation Probability:
Biowin7 (Anaerobic Linear Model): -0.9281
Ready Biodegradability Prediction: NO - Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Under the study conditions, the test substance is considered not readily biodegradable.
- Executive summary:
The ready biodegradability of the substance was predicted through EPI SUITE (BIOWIN v4.11). The substance was not found to be readily biodegradable based on overall results from several BIOWIN predictions (US EPA, 2012).
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: RA study
- Remarks:
- non-GLP; no details on test substance characteristics
- Justification for type of information:
- Refer to the section 13 for details on the read across justification.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Deviations:
- no
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, industrial, adapted
- Duration of test (contact time):
- 39 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Reference substance:
- aniline
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- > 30 - < 40
- Sampling time:
- 39 d
- Details on results:
- Kinetic of test substance (in %):
< 10 after 19 day(s)
= 0.1 ... 11.2 after 20 day(s)
= 8.9 ... 23.8 after 25 day(s)
= 21.7 ... 31 after 28 day(s)
= 37.8 ... 41.4 after 39 day(s) - Results with reference substance:
- Kinetic of control substance (in %):
< 10 after 5 day(s)
= 62.7 after 14 day(s) - Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Based on the results from the read across study, the degree of biodegradation reached 30 - 40 % after 39 days. Therefore the test substance is considered to be not readily biodegradable.
- Executive summary:
A study was conducted to determine the ready biodegradability of the read-across substance according to OECD Guideline 301 C. This study was performed in order to evaluate aerobic elimination and degradation potential of the test substance throughout a 39-day period in a test for ready biodegradability, using a nominal test substance concentration of 100 mg/mL in an activated industrial sludge, (adapted model). The degradation was followed by determination of the oxygen consumption. Measurements were taken at the following days: 19, 20, 25, 28 and 39. Based on the results of the read across study, the degree of biodegradation reached 30 - 40 % after 39 d, therefore the test substance is considered to be not readily biodegradable (BASF, 1988).
Referenceopen allclose all
Criteria for the YES or NO prediction: If the Biowin3 (ultimate survey model) result is "weeks" or faster (i.e. "days", "days to weeks", or "weeks" AND the Biowin5 (MITI linear model) probability is >= 0.5, then the prediction is YES (readily biodegradable). If this condition is not satisfied, the prediction is NO (not readily biodegradable). This method is based on application of Bayesian analysis to ready biodegradation data. Biowin5 and 6 also predict ready biodegradability, but for degradation in the OECD301C test only; using data from the Chemicals Evaluation and Research Institute Japan (CERIJ) database.
Description of key information
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
Study 1:
The ready biodegradability of the substance was predicted through EPI SUITE (BIOWIN v4.11). The substance was not found to be readily biodegradable based on overall results from several BIOWIN predictions (US EPA, 2018).
Study 2:
A study was conducted to determine the ready biodegradability of the read across substance according to OECD Guideline 301 C. This study was performed in order to evaluate aerobic elimination and degradation potential of the test substance throughout a 39-day period in a test for ready biodegradability, using a nominal test substance concentration of 100 mg/mL in an activated industrial sludge, (adapted model). The degradation was followed by determination of the oxygen consumption. Measurements were taken at the following days: 19, 20, 25, 28 and 39. Based on the results of the read across study, the degree of biodegradation reached 30 - 40 % after 39 d, therefore the test substance is considered to be not readily biodegradable (BASF, 1988).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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