ECHA Weekly - 28 August 2024

REACH

Assessment of regulatory needs report published

Reports for the following substance groups are now available on our website:

• Cyclic polysaccharides and their ether and ester derivatives

If you have questions or feedback related to the assessment work, you can send them to us using this webform.

New substance evaluation conclusions published

• N-methylaniline (EC 202-870-9, CAS 100-61-8) was evaluated by Poland in 2023. 

Testing proposals 

We have launched new consultations on 34 testing proposals.

The deadline for comments is 7 October 2024.

CLP

New intentions, a proposal and a withdrawal to harmonise classification and labelling

Nine intentions have been submitted for:

• Rosin, maleated (EC 232-480-4, CAS 8050-28-0)
• Reaction products of tall oil fatty acids and tall oil rosin with maleic anhydride (EC -, CAS -) 
• Rosin, fumarated (EC 266-040-8, CAS 65997-04-8)
• Resin acids and Rosin acids, fumarated, esters with glycerol (EC 307-051-0, CAS 307-051-0)
• Rosin, oligomers (EC 500-163-2, CAS 65997-05-9)
• cobalt bis(2-ethylhexanoate) [1]; cobalt hydroxide oxide [2]; cobalt dihydroxide [3]; cobalt oxide [4]; cobalt(II) 4-oxopent-2-en-2-olate [5]; cobalt trihydroxide [6]; cobalt sulphide [7]; cobalt(2+) propionate [8] (EC -, CAS -) 
• decan-1-ol (EC 203-956-9, CAS 112-30-1)
• Resin acids and Rosin acids, maleated, esters with pentaerythritol (EC 305-516-2, CAS 94581-17-6)
• Rosin (EC 232-475-7, CAS 8050-09-7)

A proposal has been submitted for:

• 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyran galaxolide (HHCB) (EC 214-946-9, CAS 1222-05-5)

A withdrawal has been received for:

• bis(4-methylbenzoyl)peroxide (EC 407-950-9, CAS 895-85-2)

Consultation on harmonised classification and labelling

We are looking for comments on the harmonised classification and labelling (CLH) proposal for:

• choline hydrogen phosphonate (EC -, CAS 947138-30-9)

Have your say by 25 October 2024.

IT Tools

New OECD QSAR Toolbox version available

QSAR Toolbox 4.7 enhances and expands the use of metabolism information, increases capacity to search for analogues and improves reporting of a prediction from category approach or (Q)SAR models. Along with these new implementations, many system modules including profilers, simulators, databases, documentation and caches have been updated.

The OECD QSAR Toolbox is a collaborative project between ECHA, OECD and its member and partner countries. It is used worldwide in hazard assessment of chemicals to avoid unnecessary animal testing.

Board of Appeal

New Board of Appeal decision in a compliance check follow-up case

Case A-004-2023 concerned the follow-up to a compliance check. By its initial compliance check decision, the Agency had required information on an extended one-generation reproductive toxicity study (EOGRTS). The Appellant carried out the EOGRTS but omitted certain histopathological investigations.

The Board of Appeal held that the OECD test guideline for the EOGRTS requires the histopathological investigations at issue in this case. It also found that the Appellant had not shown that there was a valid reason for omitting them. The EOGRTS needs to be completed by carrying out the missing investigations. The appeal was consequently dismissed.