Registration Dossier

Guidance on Safe Use

Guidance on Safe Use

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Administrative data

First-aid measures

Emergency measure - Inhalation: Remove subject to fresh air. Give artificial respiration if
breathing has stopped. Seek immediate medical attention.
Emergency measure - Eyes: Wash with copious amounts of water for 15 - 20 minutes. Seek
medical attention immediately.
Emergency measure - Skin: Remove contaminated clothing and wash affected area with
soap and water. Get medical attention if irritation develops
or persists.
Emergency measure - Ingestion: Rinse mouth out thoroughly with water if the subject is
conscious. Seek immediate medical attention.

Fire-fighting measures

Recommended extinguishing agent: Use agents appropriate for surrounding environment. Water or
foam are suitable.

Product arising from burning: May include CO, CO2 plus oxides of nitrogen and phosphorus.

Product determined by test: N

Protective equipment: Full protective clothing with self contained breathing
apparatus should be worn.

Accidental release measures

Emergency measures in case of spillage: Protective clothing and respirator should be worn.

Collect material to minimize dust generation; use wet mop,
damp sponge or wet/dry HEPA vacuum. Place collected
substance into a suitable container for disposal. Spill site
should be washed and ventilated.

Handling and storage

Handling: When engineering controls are not sufficient to control dust
exposure, approved respiratory protection to EN 136 standard
should be worn. For manufacturing areas skin protection
should be provided in the form of Tyvek coveralls or gowns
(or other impervious material), along with latex or other
impermeable gloves. Rubber, neoprene or other gloves may be
required if solvents, corrosives or other chemicals are
present. Chemical safety glasses should be worn if a full
face respirator is not being worn.

Storage: Store in sealed, upright fibre drums in a dry area away from
heat sources. Ensure containers are correctly labelled.

Packaging of the substance and or preparation: Fibre drums (47 x 72 cm), 34 kg maximum, UN approved.

Transport information

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Marine transport (IMDG)

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Air transport ICAO/IATA

Remarks
Transport code: No UN number has been assigned.
Transport: Use normal procedures for transport of industrial chemicals
not considered hazardous for transport. Ensure the
containers are securely held to prevent falling over.
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Exposure controls / personal protection

Local exhaust ventilation is provided at
the charging operations along with the use of supplied air
respirator and protective chemical suits to control exposure
to the employees.

Stability and reactivity

Danger other than fire: None.

Chemical reaction with water: None.

Dust explosion: Compound has been tested as a combustible dust with a class
ST-2 explosion strength (ASTM E 1226 method) As with any
organic material, a suspended dust cloud of this substance
may ignite if subject to a strong ignition source or static
electricity.

Dust explosion determined by test: Y

Disposal considerations

Industry - Possibility of recovery/recycling: SQ 28,796 is chemically cleaved during the drug synthesis
reaction in which it is employed. The break down products
are SQ 28,617 and cinchonidine salt. The SQ 28,617 is
consumed in the synthesis reaction. Cinchonidine is
recovered from the process and is re-used as feasible.

Industry - Possibility of neutralisation: No method of chemical neutralisation is known.

Industry - Possibility of destruction: controlled discharge: Trace quantities are destroyed by biological oxidation in
wastewater treatment plant (642).

Industry - Possibility of destruction - incineration: Large quantities are destroyed by incineration (663). A
closed-circuit incinerator with scrubbers should be
employed. National regulations must be observed.

Industry - Possibility of destruction - water purification: Trace quantities of material in washes generated during
cleaning operations are treated in secondary biological
wastewater treatment plant.

Industry - Possibility of destruction - other: None.

Public at large - Possibility of recovery/recycling: Material not intended for public at large therefore section
not applicable.