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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
Not reported.
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The data was presented in very limited detail and so it was not possible to assess the accuracy of the data from the information presented.

Data source

Reference
Reference Type:
review article or handbook
Title:
Range Finding Toxicity Data: List VII
Author:
Smyth H, Carpenter C, Weil C, Pozzani U, Striegel J & Nycum J
Year:
1969
Bibliographic source:
American Industrial Hygiene Association Journal 30:5, 470-476

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Various volumes of test material, in water or propylene glycol, were instilled in the eye of rabbits. Eye reactions were observed and graded according to the 10-grade ordinal series based upon the degree of resultant corneal necrosis. The methodology is reported in Smyth et al (1962).
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): 1,2-epoxycyclohexane

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
other: water or propylene glycol
Controls:
not specified
Amount / concentration applied:
The test material was dosed in a 1% solution in water or propylene glycol. The volume and concentration both varied.
Details on study design:
Scored against a 10-grade ordinal series, bases on the degree of corneal necrosis.

Grade 1 - a very small area of necrosis resulting from 0.5 mL of undiluted chemical
Grade 5 - severe burn from 0.005 mL
Grade 10 - severe burn form 0.5 mL of a 1% solution in water or propylene.

Results and discussion

In vivo

Results
Irritation parameter:
cornea opacity score
Basis:
other: not reported.
Score:
8
Max. score:
10
Remarks on result:
other: No data available for the time point, max. score or reversibility.

Any other information on results incl. tables

No further information on results is reported.

Applicant's summary and conclusion

Interpretation of results:
highly corrosive
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Under the conditions of the test a strong response was seen in the cornea of the test animals, which permits classification as highly corrosive by expert judgement.
Executive summary:

Various volumes of test material, in water or propylene glycol, were instilled in the eye of rabbits. Eye reactions were observed and graded according to the 10-grade ordinal series based upon the degree of resultant corneal necrosis. Under the conditions of the test a strong response was seen in the cornea of the test animals, which permits classification as highly corrosive by expert judgement.