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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Not reported
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study report is presented in an abstract; very little information is available regarding the method of exposure. It is therefore not possible to assess the accuracy of the data.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1975
Report Date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Irritation and corrosivity observations were performed as part of an aucte dermal toxiicty study. The test material was held in prolonged contact with the skin of a rabbit and the resultant skin reaction was noted.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): cyclohexene oxide

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
The test animal was exposed for 24 hrs.

Results and discussion

In vivo

Irritant / corrosive response data:
Exposure to the test material resulted in moderate to severe chemical burns.
Other effects:
The LD50 of the test material was greater than 1000 mg/kg bw.

Applicant's summary and conclusion

Interpretation of results:
highly corrosive
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Under the conditions of the study, the test material was shown to cause a severe reaction to the skin, leaving chemical like burns.
Executive summary:

The irritation potential of the test material to the skin was determined in an unspecified species of rabbit. The study records that moderate to severe chemical burns were caused as a result of dermal exposure over a 24 hour period. There is no available information regarding the methods used, so it is not possible to assess the accuracy of the data from the available information.