Registration Dossier

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Not reported.
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: A non-GLP study conducted to scientific principles with a sufficient level of detail to assess the quality of the presented results.

Data source

Reference
Reference Type:
review article or handbook
Title:
The Pharmacology of Certain Terpene Alcohols & Oxides
Author:
Northover B J & Verghese J
Year:
1962
Bibliographic source:
Journal of Scientific & Industrial Research, Vol. 21C,No. 12, 342-345

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Groups of 10 mice received intramuscular injections of test material at graded doses. Mortality was observed during the 48 hours following treatment to allow determination of an LD50 value.
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): cyclohexene oxide

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intramuscular
Vehicle:
not specified
Doses:
4, 6, 8, 10 and 12 g/kg
No. of animals per sex per dose:
10 animals per dose
Control animals:
not specified
Details on study design:
Animals were exposed via intramuscular injections in groups of 10 to graded doses of the test material.
The animals were observed for 48 hours following treatment with the test material and deaths were recorded.
Statistics:
The number of animals which died was plotted against the dose administered to calculate the LD50.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 other: g/kg
Based on:
test mat.

Any other information on results incl. tables

No further information on results is presented.

Applicant's summary and conclusion

Conclusions:
The acute toxicity of the test material was determined by administering test material to mice by intramuscular injection. Under the conditions of the study, the LD50 of the test material was determined to be 1000 mg/kg body weight.
Executive summary:

Groups of 10 mice received intramuscular injections of test material at graded doses. Mortality was observed during the 48 hours following treatment to allow determination of an LD50 value. Under the conditions of the study, the LD50 of the test material was determined to be 1000 mg/kg body weight.