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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Not reported.
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study report is presented with very little information available regarding the method of exposure. It is therefore not possible to assess the accuracy of the data.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1948
Report Date:
1948

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rats were exposed to vapour of test material on two successive days, the first exposure being for 1.5 hours to a nominal concentration of 2500 ppm and the second for 2.5 hours to 1500 ppm. Animals were sacrificed the day following the second exposure and subject to a pathological assessment.
GLP compliance:
not specified
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: vapour
Details on test material:
- Name of test material (as cited in study report): cyclohexene oxide

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
Test animals were exposed twice on two consecutive days.

1ST EXPOSURE
Duration: 1.5 hrs.
Nominal concentration: 2500ppm.

2ND EXPOSURE
Duration: 2.5 hrs.
Nominal concentration: 1500ppm.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Remarks on duration:
1st and 2nd exposure durations combined
Concentrations:
1ST EXPOSURE
Duration: 1.5 hrs.
Nominal concentration: 2500ppm.

2ND EXPOSURE
Duration: 2.5 hrs.
Nominal concentration: 1500ppm.
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
Animals were sacrificed the day after the last exposure.

Results and discussion

Mortality:
no data
Clinical signs:
Irritation to the eyes and respiratory tract were observed.
Body weight:
no data
Gross pathology:
Slight peribronchial oedema was observed.

Any other information on results incl. tables

No further information on results is reported.

Applicant's summary and conclusion

Interpretation of results:
other: not possible to derive classification from data presented
Remarks:
Criteria used for interpretation of results: expert judgment
Conclusions:
Under the conditions of the study, irritation of eyes and upper respiratory tract were noted; when sacrificed after second exposure, slight perbronchial oedema was evident.
Executive summary:

The acute inhalation toxicity of the test material was tested by exposing rats to 2500 ppm for 1.5 hrs on day one and 1500 ppm for 2.5 hrs on day two. The observations reported were irritation to the eyes and upper respiratory tract, and perbronchial oedema. The specific details regarding the method are not available. It is not possible to assess the accuracy of the data from the information provided. The study cannot be used to derive a classification according to Regulation 1272/2008, however, it supports the conclusion that the test material causes respiratory irritation.