Registration Dossier

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
not reported
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study report is presented with very little information available regarding the method of exposure. It is therefore not possible to assess the accuracy of the data.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1948
Report Date:
1948

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Up to 6 mL/kg test material was applied to the shaved skin of rabbits. Following application, the test material was allowed to evaporate spontaneously with the animals placed in a fume hood. Skin absorption and toxicity of the test material were recorded.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): cyclohexene oxide
Radiolabelling:
not specified

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
The test material was applied directly to the skin and allowed to evaporate spontaneously.
The animals were placed in a hood to prevent inhalation of the test material.
Doses:
Up to 6 mL/kg
Details on study design:
Up to 6 mL/kg test material was applied to the shaved skin of rabbits. Following application, the test material was allowed to evaporate spontaneously with the animals placed in a fume hood. Skin absorption and toxicity of the test material were recorded.

Results and discussion

Signs and symptoms of toxicity:
no effects
Dermal irritation:
not specified
Absorption in different matrices:
Low absorption by the skin, thought to be caused by the rapid evaporation.

Any other information on results incl. tables

Minimal fatal dose was determined to be > 6 mL/kg.

Applicant's summary and conclusion

Conclusions:
The test material was determined to have a low rate of skin absorption thought to be caused by the rapid evaporation of the test material from the surface of the skin.
Executive summary:

The dermal absorption of the test material was determined by applying test material to the skin of rabbits and assessing resultant toxicity. The test material was applied and left to evaporation spontaneously. The minimum fatal dose was determined to be > 6mL/kg. The low skin absorption was considered to be caused by the rapid evaporation of test material from the surface of the skin.