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Description of key information

Short description of key information on bioaccumulation potential result: 
The bioaccumulation potential of the test material was shown, by both in vivo and in vitro methods, to be very low. Regardless of the route of exposure the test material was readily excreted predominantly in the urine; there was little absorption and the test material was readily metabolised.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

Three studies have been provided to address the bioaccumulation endpoint on a weight of evidence basis.

Jerina (1968) assessed the metabolism of the test material in an in vitro study. The test material was incubated with a microsomal preparation of rabbit liver. Under the conditions of the test it was determined that the test material was hydrolysed by the liver enzyme, epoxide hydrase to form the metabolite 1,2-cyclohexanediol. Sauer (1977) assessed the absorption, distribution, metabolism and excretion of radiolabelled test material in vivo. There were three parts to the study; radiolabelled test material was dosed orally, dermally and intravenously. Both rats and mice were exposed in the oral and dermal applications; only rats were used for the intravenous exposure. Regardless of the route of exposure the test material was predominantly excreted in the urine, there was little absorption and the test material was readily metabolised. Both Jerina (1968) and Sauer (1977) were performed to sound scientific principles and have been assigned a reliability score of 2, according to the principles of assessing data accuracy set out in Klimisch (1977).

Foulger (1948) has also been provided as supporting data. During the study, rabbits were exposed to the test material via topical application. The minimum fatal dose was determined to be > 6ml/kg. The low absorption was considered to be caused by the rapid evaporation from the surface of the skin. The study have been assigned a score of 4, according to Klimisch (1977), as there is incomplete reporting of methodology and thus it is not possible to assess the accuracy of the data.