3-(triethoxysilyl)propanethiol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1976

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Remarks:

The study was conducted according to a generally accepted protocol, but not in compliance with GLP and with insufficient reporting of results.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

no guideline followed

GLP compliance:

no

Test type:

fixed concentration procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

3-(triethoxysilyl)propanethiol

EC Number:

238-883-1

EC Name:

3-(triethoxysilyl)propanethiol

Cas Number:

14814-09-6

Molecular formula:

C9H22O3SSi

IUPAC Name:

3-(triethoxysilyl)propane-1-thiol

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
Concentrated vapour is generated in a gas washing bottle by passing dried air at 2.5 l/min through a fritted glass disc immersed to a depth of at least 1 -1/2 inches in the chemical which is delivered to rats in a 9-litre glass exposure chambre. Mean vapour concentration is calculated from the loss in weight of the liquid or estimated from the vapour pressure at the actual temperature of the chemical during aeration.

Vapor dynamically generated at 21C, chamber temperature at 23C.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

Substantially saturated vapour

No. of animals per sex per dose:

6

Control animals:

no

Statistics:

Not specified

Results and discussion

Mortality:

None

Clinical signs:

other: None

Body weight:

Body weight change reported as '86-92'

Gross pathology:

Reported as nothing remarkable

Other findings:

None reported

Any other information on results incl. tables

No hazard is anticipated from the infrequent inhalation of substantially saturated vapour generated at room temperature under normal handling conditions.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

In a non-guideline / pre-GLP study, no deaths were reported in rats (species, gender not specified) exposed for 8 hours to substantially saturated vapour of 3-(triethoxysilyl)propanethiol. The reliability of the study is considered not assignable (reliabilty score 4) due insufficient documentation.