Registration Dossier
Registration Dossier
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EC number: 463-070-5 | CAS number: 106966-25-0
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08.10.-08.11.2007.
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- Directive 92/69/EEC. Published in OJ No L 383 A, December 1992
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 463-070-5
- EC Name:
- -
- Cas Number:
- 106966-25-0
- Molecular formula:
- C7H17N2O2Br
- IUPAC Name:
- 2-(3-methoxy-3-oxopropyl)-1,1,1-trimethylhydrazinium bromide
Constituent 1
Study design
- Buffers:
- Buffer mixtures - Clark and Lubs
pH=4 - Details on test conditions:
- HPCE conditions:
Capillary: CE capillary (Agilent), 80 cm long, Eff.length 72 cm, ID 50 micrometres, extended light path
Temperature: 25 C
Running buffer: 5 mM 2-aminobenzimidazole/ 0.004 mM H2SO4 + 0.0008 mM HCl, pH=2.5
Voltage: 30 kV, positive
Detection: 275 nm, indirect UV (sample 400/40 nm, reference 275/10 nm)
Injection: hydrodynamic, 50 mbar * 40 s
Results and discussion
- Preliminary study:
- pH 4: Less than 10% of the test substance underwent the hydrolysis within a 5 days period at 50 ˚C. A half-life time of hydrolysis at 25 ˚C and pH 4 can be expected higher than 1 year.
pH 7: More than 10% of the test substance underwent the hydrolysis within a 5 days period at 50 ˚C but less than 50% hydrolysed in 2.4 hours. . A half-life time of hydrolysis at 50 ˚C and pH 7 was estimated to 2.8 hours.
pH 9: More than 50% of the test substance underwent the hydrolysis in 2.4 hours. A half-life time of hydrolysis at 50 ˚C and pH 9 was estimated to 1.3 hours. A half-life time of hydrolysis at 25 ˚C can be expected lower than 1 day - Transformation products:
- not specified
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 8 760 h
- pH:
- 7
- Temp.:
- 50
- DT50:
- ca. 67.2 h
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- < 24 h
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- 1.3 h
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
