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EC number: 701-315-2
CAS number: -
examined for mutagenic activity in four histidine-dependant auxotrophs
of Salmonella typhimurium (TA98,
TA100, TA1535, and TA1537) and in Escherichia coli strain WP2
the absence or presence of S9, using
both the pre-incubation method (Test 1) and plate incorporation method
(Test 2). The test was conducted according to OECD Test Guideline 471
and to GLP.
material did not induce two-fold increases in the number of revertant
colonies in the pre-incubation or plate incorporation assay, at any
dose-level, in any tester strain, in the absence or presence of S9. In
both tests, precipitation was noted at 2500 ug/plate and above, and also
at 1600 ug/plate in test 1. Toxicity, as indicated by thinning of the
background lawn, was observed at higher dose levels in all tester
strains (with and without S9), except TA98.
evidence of mutagenic activity was detected in
TA100, TA1535, and TA1537, or in Escherichia
WP2 uvrA, tested with Pt-divinyltetramethyldisiloxane
up to 5000 ug/plate in the presence or absence of S9.
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