Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
17 September 1998
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1999
Report Date:
1999

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to
Guideline:
other: EC Method A.8
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
ca. 5.2
Remarks on result:
other: Temperature
Remarks:
Temperature was not recorded.
Details on results:
From the primary data a calibration curve was generated.
The mean calibration curve was used to interpolate the results.
The mean calibration curve produced was:
logio Pow = 3.12 log iok + 1.95
Where k = capacity factor
k = t'r/to = (tr-to)/to
and t', = true retention time obtained by subtracting deadtime, or to, of I.D.S. from measured
retention time of sample or reference.
A log Pow, value of 5.2 was thus obtained for CP-163,625-BV.

Applicant's summary and conclusion

Conclusions:
CP-163,625-BV was determined to have a log Pow value of 5.2
Executive summary:

CP-163,625-BV was determined to have a log Pow value of 5.2