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EC number: 944-870-8
CAS number: -
objective of the present study was to identify potential toxic effects
of the test item after single oral administration to rats in a stepwise
procedure according to OECD TG 423. The
treatment was started with 2000 mg/kg body weight in 3 female rats and
continued with further 3 females treated with 2000 mg/kg. Mortality and
clinical signs were monitored for at least 6 hours after administration
and then daily. All animals were weighed before treatment (day 1) and on
days 2, 4, 6, 8, 11, 13, and 15. At the end of the observation period,
all surviving rats were sacrificed and subjected to a detailed necropsy. No
mortality occurred during the course of this study. No clinical signs of
toxicity were observed. The
body weight development was inconspicuous throughout the study. The
gross pathological examination revealed no organ alterations.
test item has no acute toxic potential under the conditions of the
present study, and the LD50 value is higher than 2000 mg/kg bw after
single oral administration in female rats.
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